颅内出血足月新生儿治疗前后血浆IL-6、TNF-α变化的临床分析

Clinical analysis on the levels of IL-6 and TNF-α in blood plasma of neonates with intracranial haemorrhage before and after therapy

目的探讨颅内出血足月新生儿治疗前后血浆中白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平变化的临床意义。方法采用ELISA法测定50例颅内出血足月新生儿治疗前后血浆IL-6、TNF-α水平的变化,并与对照组进行对比分析。结果与对照组相比,颅内出血足月新生儿治疗前血浆IL-6、TNF-α水平明显升高;IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较,差异具有统计学意义(P<0.05);治疗后,颅内出血患儿血浆IL-6和TNF-α水平均明显降低(P<0.05)。结论颅内出血足月新生儿血浆IL-6、TNF-α水平明显增高,可作为判断病情,观察治疗效果和评估预后的指标,可能对新生儿颅内出血后继发性脑损伤发病机制研究具有一定的意义。

[ Objective ] To explor the changes and clinical significance of serum levels of interleukin-6（IL-6）and tumor necrosis factor- α in newborns with intracranial hemorrhage before and after therapy. [ Methods ] The levels of IL-6 and TNF- α in blood plasma in 50 neonates with intracranial haemorrhage （case group） both before and after therapy and 26 healthy neonates （control group） were detected by ELISA. [ Results ] The levels of IL-6 and TNF- α in case group were significantly higher than those in control group （P〈0.05）; there was significant difference in levels of IL-6 and TNF-α between different amounts of bleeding group （P〈0.05）;After therapy IL-6 and TNF- α levels were dramatically lower （P〈0.05）. [ Conclusion ] Serum levels of IL-6 and TNF- α increases obviously in newborns with intracranial hemorrhage, suggesting that they might be used as reference index in assessing pathogenetic condition, indicating therapeutic and aDnraising prognosis.