艾迪注射液治疗15例高凝状态结直肠癌的临床观察

Clinical Observation on 15 Colorectal Cancer Patients in Blood Hypercolktive State Treated with Aidi Injection

目的观察艾迪注射液对血浆D-二聚体的干预作用,探讨其对结直肠癌患者高凝状态的影响。方法筛选30例D-二聚体异常升高的具有复发高危因素Dukes’B期以上的结直肠癌患者,随机分为对照组与治疗组,每组15例,均采用标准FOLFOX或XELOX方案化疗,治疗组联合使用艾迪注射液,在疗程前后用免疫比浊法测定血浆D-二聚体值。结果对照组D-二聚体升高10例,降低5例,均值在治疗前后统计学无差异;治疗组D-二聚体升高3例,降低12例,均值在治疗前后差异有统计学意义(P<0.01),并且2组D-二聚体降低率的差异具有统计学意义(P<0.05),二者治疗前后D-二聚体的净效应之间差异有统计学意义(P<0.01)。结论艾迪注射液可降低高凝状态结直肠癌患者的D-二聚体水平,化疗对结直肠癌患者的D-二聚体水平无显著影响。

OBJECTIVE To explore the intervention effect of Aidi injection on blood hypercolktive state of 15 patients with advanced colorectal cancer by means of testing plasma D-dimer’s levels. METHODS Thirty cases with colorectal cancer with abnormal D-dimer values were randomly divided into control group and treatment group, 15 cases in each group, and treated with chemotherapy or Aidi injection combining chemotherapy separately. Their plasma D-dimer concentrations were measured by immunoturbidimetric assay before and after treatment. RESULTS D-dimer concentrations of 10 cases in control group rose, the others reduced. No significant difference was found before and after treatment. D-dimer concentrations of 3 cases in treatment group rose, the others reduced. A significant difference of mean was found before and after treatment（P〈0.01）. The rate of decline and the deviation values of D-dimer were statistically significant difference between two groups（P〈0.05 and P〈0.01）. CONCLUSION Aidi injection can ameliorate D-dimer concentrations of large intestine patients in blood hypercolktive state. Chemotherapy does not influence the plasma D-dimer concentrations of patients with colorectal cancer.