五味子乙素的药理作用及其分子机制的研究进展

Advance in Study on Pharmacological Effect and Molecular Mechanisms of Schisandrin B

五味子是木兰科植物五味子的干燥成熟果实,是著名的滋补性中药,习称"北五味子"。其单体活性成分五味子乙素具有保肝、抗炎、抗肿瘤及抗氧化等多种药理作用,临床广泛应用于肝病的防护与治疗、心脑血管疾病、多种神经退行病变等领域。现对五味子乙素的药理作用、安全性及生物利用度等相关国内外最新研究现状作一系统综述,为进一步研究、开发和合理应用五味子乙素提供参考。

Schisandra, the dried ripe fruit of Schisandra chinesis （Turcz.） Baill, is a topic traditional Chinese medicine, often called ＂Schisandra chinesis＂. Its single active ingredient of schizandrin （Schisandrin B） has a variety of pharmacological effects, such as hepatoprotective, anti-inflammatory, anti-tumor, anti-oxidation and so on. The schizandrin is widely applied in liver protection and treatment, cardiovascular and cerebrovascular diseases, a variety of neurodegenerative diseases in clinical. Our paper make a systematic review of recent related research at home and abroad which study the pharmacological effects, safety and bioavailability of the schizandrin.