水化对肾灌注造影患者造影剂肾病的影响

Effect of hydration in prevention of contrast-induced nephropathy after renal perfusion imaging

目的观察水化对冠状动脉造影患者肾功能的影响。方法收集2011年9月至2013年8月2型糖尿病(T2DM)患者25例,应用低渗非离子型造影剂进行肾灌注造影,造影前及造影后第1、3天分别测定患者的血葡萄糖、24 h尿微量白蛋白、24 h尿蛋白定量、血尿素氮、血肌酐等各项指标,评价造影剂肾病的发生情况及肾功能的变化情况。结果 T2DM患者灌注造影后均未发生CIN。造影灌注后第1、3天24 h微量白蛋白、24 h蛋白定量、血尿素氮、血肌酐与造影前比较差异均无统计学意义(P>0.05)。结论加强水化能减轻肾功能伤害,减少造影剂肾病的发生率。

Objective To observe the effects of hydration on renal function in patients undergoing renal per- fusion imaging. Methods Twenty-five patients of type 2 diabetes mellitus （T2DM） admitted into our hospital from Sep. 2011 to Aug. 2013 were recruited in this study. The low osmolar and nonionic contrast media was used in all pa- tients. The blood glucose, 24 h urinary albumin, 24 h urinary protein, blood urea nitrogen, ereatinine and other indica- tors of the patients were detected before imaging, 1 day and 3 days after imaging. The incidence of contrast-induced nephropathy and renal function changes were evaluated. Results No patient suffered contrast-induced nephropathy （CIN） after perfusion imaging. The 24 h urinary albumin, 24 h urinary protein, blood urea nitrogen and creatinine didn＇t have significant changes before imaging, 1 day and 3 days after imaging （P〉0.05）. Conclusion The strength- ened hydration therapy can reduce the renal damage and effectively prevent contrast-induced nephropathy.