EV-71感染手足口病患儿血神经元特异性烯醇化酶水平变化及其临床意义

Effect of EV-71 infection on level of serum neuron-specific enolase in children with hand-foot-mouth disease and the clinical significance

目的观察EV-71感染对手足口病患儿血清神经元特异性烯醇化酶(NSE)水平的影响,探讨其感染与神经系统损伤的相关性,为潜在神经系统损伤的早期干预及治疗提供理论依据。方法随机收集2011年4月至2012年11月间在本院儿内科治疗的100例手足口病患儿的临床资料,依据血清EV-71抗体检测结果分为阳性组43例和阴性组57例;同时选择在本院保健科进行体检的健康儿童80例作为对照组。应用电化学发光法进行血清NSE含量测定。对手足口病组和对照组、EV-71阳性组和阴性组血清NSE值进行对比分析。结果手足口病组和对照组比较,血清NSE水平偏高,差异有显著统计学意义(P<0.01);EV-71阳性组和阴性组患儿比较,血清NSE水平明显高于阴性组,差异有显著统计学意义(P<0.01)。结论手足口病患儿血清NSE水平较正常儿童有明显偏高,EV-71阳性患儿最为明显,提示手足口病患儿较正常儿童易并发神经系统损伤,EV-71感染的手足口病患儿神经系统损伤相对更为严重。

Objective To explore the effect of EV-71 infection on level of serum neuron-specific enolase （NSE） in children with hand-foot-mouth disease （HFMD）. Methods A total of 100 children with HFMD in our hos- pital were randomly collected from April 2011 to November 2012 and enrolled as the HFMD group. The patients were divided into two subgroups according to the results of virus EV-71 antibody detection： EV-71 positive sub- group （n--43） and EV-71 negative subgroup （n=57）. Eighty healthy children were selected as the control group. Che- miluminescent methods were performed to detect serum NSE in different groups, which was then compared between the groups. Results Serum NSE level was higher in HFMD group than that in control group （P〈0.01）, and higher in EV-71 positive subgroup than that in EV-71 negative subgroup （P〈0.01）. Conclusion The level of serum NSE is higher in children with HFMD than that in healthy children, and it is also significantly higher in EV-71 positive pa- tients, which indicates that children with HFMD predispose to nervous system damage, especially those with virus EV-71 infection.