饮食和运动干预对妊娠期糖尿病患者血浆脂肪因子调控的实验研究

Experimental study of diet and exercise intervention on plasma adipokine regulating gestational diabetes

目的观察饮食和运动干预对妊娠期糖尿病患者血浆脂肪因子调控的影响。方法选择妊娠期糖尿病孕妇139例:65例为观察组、74例为饮食和运动干预组;同期进行健康体检孕妇20例作为对照组;治疗前、后159例孕妇均为空腹采血。采用全自动生化分析仪检测血脂水平;采用ELISA法检测血浆中各脂肪因子的水平。结果治疗前与对照组比较,观察组和饮食、运动干预组血浆中血脂和各脂肪因子水平均明显增高有统计学意义(P<0.01);治疗后与对照组比较,观察组孕妇血浆中血脂和各脂肪因子水平仍处于高水平状态有统计学意义(P<0.01),饮食、运动干预组孕妇血浆中血脂和各脂肪因子水平均降低无统计学意义(P>0.05);治疗后与观察组比较,饮食、运动干预组孕妇血浆中血脂和各脂肪因子水平均降低有统计学意义(P<0.01)。结论饮食和运动干预对妊娠期糖尿病患者血浆中血脂和脂肪因子的调控疗效可靠,具有临床推广价值。

Objective To observe the diet and exercise intervention on patients with gestational diabetes fat factor regulation effect.Methods 139 cases of pregnant women with diabetes during pregnancy：65 cases in the observation group,74 cases of diet and exercise intervention group;concurrent healthy pregnant women,20 cases of the control group;before and after treatment were 159 cases of pregnant women,fasting blood.Using automatic biochemical analy-zer lipid levels;detected by ELISA in plasma levels of adipokines.Results Before treatment compared with the control group,the observation group and diet,exercise intervention group and the plasma lipid levels were significantly higher in fat factor was statistically significant（P 〈0.01）;treatment compared with the control group,the observation group in maternal plasma lipids and various adipokines levels remained high status was statistically significant（P 〈0.01）,diet and exercise intervention group in maternal plasma lipids and various adipokines levels were not statistically significant reduction（P ＆gt;0.05）;treatment with observation group,diet,exercise intervention group in maternal plasma lipids and various adipokines levels decreased statistically significant（P 〈 0.01）.Conclusion diet and exercise intervention on plasma lipids in patients with gestational diabetes and regulation of adipokines effective and reliable,has clinical value.