β-HCG、VEGF和孕酮联合检测在早期异位妊娠诊断中的价值

Diagnosis value of combined detection of serumβ-HCG、VEGF and progesterone levels in early ectopic pregnancy

目的观察早期异位妊娠患者血清β-人绒毛膜促性腺激素(β-HCG)、血管内皮生长因子(VEGF)和孕酮含量变化,并分析其在早期异位妊娠诊断中的价值。方法选择100例未能确诊的疑似异位妊娠患者作为研究对象,将最终确诊为异位妊娠的50例患者设为研究组;宫内妊娠的50例患者设为对照组。采用ELISA法检测两组患者血清VEGF含量,采用放射免疫法检测两组患者血清β-HCG和孕酮含量。结果与对照组比较,研究组患者β-HCG和孕酮含量明显降低,VEGF含量明显升高,差异具有统计学意义(P<0.05)。β-HCG单独检测的敏感度、特异度和准确度分别为68.0%、72.0%和70.0%,VEGF单独检测的敏感度、特异度和准确度分别为70.0%、74.0%和72.0%,孕酮单独检测的敏感度、特异度和准确度分别为74.0%、78.0%和76.0%。β-HCG、VEGF和孕酮联合检测的敏感度、特异度和准确度分别为92.0%、52.0%和93.0%,β-HCG、VEGF和孕酮联合检测的敏感度、特异度和准确度明显优于各标志物单独检测(P<0.05)。结论联合检测血清β-HCG、VEGF和孕酮含量作为临床早期异位妊娠诊断的有效指标,值得推广应用。

gesterone levels.Results Comparing with control group,serumβ-HCG and progesterone levels of research group de-creased,and serum VEGF levels increased,the difference was statistically significant（P 〈0.05）.The sensitivity、speci-ficity and accuracy ofβ-HCG was 68.0%、72.0% and 70.0%,the sensitivity、specificity and accuracy of VEGF was 70. 0%、74.0% and 72.0%,the sensitivity、specificity and accuracy of progesterone was 74.0%、78.0% and 76.0%.The sensitivity、specificity and accuracy ofβ-HCG、VEGF and progesterone was 92.0%、52.0% and 93.0%,which was bet-ter than that each detection（P 〈0.05）.Conclusion Combined detection of serumβ-HCG、VEGF and progesterone lev-els will help to diagnose early ectopic pregnancy,it is worthy of clinical application.