噻唑腙1-(1-苯基乙酰基)-2-(噻唑[5,4-b]吡啶基)肼的合成及结构表征

Synthesis and Characterization of a Thiazole-Hydrazone Compound 1-(1-phenylethylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)hydrazine

文章从2-氯-3-氨基吡啶出发,经四步反应合成了一个含噻唑的腙类化合物1-(1-苯基乙酰基)-2-(噻唑[5,4-b]吡啶基)肼,并通过红外、核磁及X-射线单晶衍射等表征了该化合物的结构。该化合物的晶体属单斜晶系,P2(1)/c空间群,晶胞参数:a=11.671(8)?,b=9.435(6)?,c=13.120(9)?,β=116.340(6)°,V=1294.7(15)?3,Z=4,Dc=1.377 mg/m3,R1=0.0406。该化合物通过分子间氢键作用形成一维链状结构。

In the paper, a thiazole-hydrazone compound, namely, l-（I-phenylethylidene）-2-（thiazolo[5,4-b]pyridin-2-yl）hydrazine, has been synthesized from 2-chloro-3-amino pyridine and characterized by IR, ~H NMR and X-ray single crystal diffraction. The compound crystallizes in monoclinic system, space group P2（1）/c with a=11.671（8）（A）,b=9.435（6）（A）,c=13.120（9）（A）,β=116.340（6）°,V=1294.7（15）（A）3,Z=4,Dc=1.377 mg/m3,R1=0.0406. The molecular species are linked by intermolecular N-H--.N hydrogen bonds into 1D chains.