盐酸吗啡缓释片不同给药途径对缓解癌症疼痛的分析研究

Research on the effect of morphine hydrochloride sustained-release tablets given by different administration routes on patients with cancer pain

目的:分析研究盐酸吗啡缓释片不同给药途径对肿瘤患者癌症性疼痛的缓解作用。方法:选择中、晚期癌症患者168例,均接受盐酸吗啡缓释片进行疼痛治疗,根据给药途径不同随机分为接受口服给药的对照组和接受直肠给药的观察组,分析两组患者治疗后的疼痛缓解程度、镇痛起效时间以及不良反应发生率等指标差异。结果:治疗后观察组患者的总缓解率为94.05%(79/84),与对照组患者无明显差异;治疗后观察组患者的平均起效时间为(0.68±0.17)h,明显短于对照组患者,且各时间段的镇痛起效百分率均高于对照组患者;治疗后观察组患者的不良反应总发生率为2.38%(2/84),明显低于对照组患者。结论:盐酸吗啡缓释片直肠给药途径可以显著缓解肿瘤患者的癌症性疼痛,提高镇痛起效时间,且不会增加患者不良反应发生,具有良好的治疗安全性。

Objective：To analyze the effect of morphine hydrochloride sustained-release tablets given by different administration routes on patients with cancer pain.Methods： Chosen patients with cancer pain as research subjects, underwent morphine hydrochloride sustained-release tablets for treatment of pain, randomized to receive oral administration as control group and rectally administration as observation group, observed pain relief degree, onset time of analgesia and adverse reaction rates.Results：1）After treatment, the observation group patients’ overall response rate was 94.05%,no significant difference compared with the control group; 2） After treatment, the observation group patients had a mean onset time （0.68 ＆#177;0.17） h, significantly shorter than the control group,0.5h, 1h, 2h, 4h of onset percentages of analgesia were higher than control group; 3）After treatment, the observation group patients’ incidence of adverse reactions was 2.38%, significantly lower than the control group.Conclusion： The morphine hydrochloride sustained release tablets rectal administration route can significantly alleviate cancer pain, shorten onset time of analgesia, and don’t increase the incidence of adverse reactions.