两种波长LED窄谱紫外线联合药物治疗白癜风的临床疗效研究

Clinical study on the treatment of vitiligo with two narrow band ultraviolet LED combined with drugs

目的:观察比较308 nm LED窄谱中波紫外线联用他克莫司与365 nm LED窄谱长波紫外线联用8-甲氧补骨脂素照射治疗白癜风的临床疗效。方法:选取64例白癜风患者采用随机数字表法分为对照组及观察组,每组32例,对照组采用308 nm LED窄谱中波紫外线联用他克莫司照射治疗,观察组采用365 nm LED窄谱长波紫外线联用8-甲氧补骨脂素照射治疗,对比两组患者治疗后出现第一个色素岛的照射次数以及治疗10次、20次后的临床疗效。结果:观察组与对照组出现第一个色素岛的平均照射次数分别为5.59和6.24次,其差异无统计学意义(t=1.772,P>0.05)。对照组治疗20次后有效率为37.50%,观察组治疗20次后有效率为40.63%,两种治疗方法的治疗效果差异无统计学意义(x2=0.000,P>0.05)。结论:308 nm LED窄谱中波紫外线联用他克莫司与365 nm LED窄谱长波紫外线联用8-甲氧补骨脂素照射治疗白癜风均具有显著的临床治疗效果,如何提高治疗效果尚需进一步深入研究。

Objective：To observe the clinical curative effect of narrow-band UVB-LED （308nm） combined with tacrolimus, narrow-band UVA-LED （365nm） combined with 8-Methoxypsoralen irradiation in the treatment of vitiligo.Methods： Sixty-four cases of vitiligo patients were chosen and randomly divided into control group and observation group, each group with 32 cases. The control group received 308nm narrow-band UVB-LED irradiation combined with tacrolimus,the observation group received 365nm narrow-band UVA-LED irradiation combined with 8-Methoxypsoralen, the time of appreance of the first pigment island in patients were compared between the two groups,the clinical curative effect of both groups were observed when treated with 10 times and 20 times.Results： The average irradiation times when first pigment island appreance in the observation group and the control group were 5.59 and 6.24 respectively, the difference was not statistically significant （t=1.772,P＆gt;0.05）. The efficiency rate of the control group was 37.50% after 20 times treatment, and in the observation group was 40.63%, the difference was not statistically significant （x2=0.000,P＆gt;0.05）.Conclusion： 308nm narrow band UVB-LED combined with tacrolimus and 365nm narrow-band UVA- LED combined with 8- Methoxypsoralen irradiation in the treatment of vitiligo have significant treatment effects, how to improve the treatment effect still need further study.