慢性乙型病毒性肝炎中医辨证分型与肝功能指标相关性研究

Correlation between TCM Syndrome of Chronic Hepatitis B and Liver Function

目的:探讨慢性乙型病毒性肝炎其中医辨证分型与西医肝功能检测指标间的相关性。方法:随机抽选235例慢性乙肝患者,根据其临床征象辩证为肝郁脾虚(74例)、湿热中阻(80例)、脾肾阳虚(20例)、肝肾阴虚(25例)以及瘀血阻络(36例)5组,比较5种证型肝功能(ALT、AST、ALT/AST、TBIL、DBIL)等指标的检测差异。结果:湿热中阻、肝郁脾虚两型中ALT(235.77±113.31、197.34±83.39)μ/L、AST(184.53±73.85、135.61±62.17)μ/L指标明显高于其他三型(P<0.05);湿热中阻型患者TBIL(45.77±43.31)μmol/L、DBIL(34.53±33.85)μmol/L显著高于其他4组(P<0.05),其他证型TBIL、DBIL均处于正常范围。结论:不同中医辨证分型,其患者部分肝功能指标亦存在不同程度的差异性,中医证型与肝功能指标二者具有相关性。

Objective ： To explore the correlation of TCM syndrome of chronic hepatitis B and liver function type. Methods ： 235 patients with chronic hepatitis B were chosen. According to their clinical signs, they were divided into liver depression and spleen deficiency group（ 74 cases ）, damp - heat resistance group （80 cases）, spleen and kidney Yang deficiency group （20 cases）, liver and kidney Yin deficiency group （25 cases） and blood stasis blocking collaterals group （36 cases）. The liver functions （ALT, AST,ALT/AST,TBIL,DBIL） of the five groups were compared. Results ：ALT（235.77 ± 113.31,197.34 ± 83.39 ） la/L and AST （184.53 ± 73.85,135.61±62.17）μl/L in damp -heat resistance group and liver depression and spleen deficiency group were significantly higher than those of the other three groups （ P 〈 0. 05 ）. TBIL （45.77±43.31 ）μmol/L and DBIL （ 34.53 ± 33. 85 ） μmol/L in damp - heat resistance group were significantly higher than those of the other four groups （ P 〈 0.05 ）. TBIL and DBIL in other syndrome groups were in the normal range. Conclusion ： Different TCM syndromes of hepatitis B have different de- grees of liver functions and there is a correlation between the TCM syndrome and liver function.