职业性暴露二甲基甲酰胺工人的血清胃动素、胃泌素和血管活性肽水平研究

A study on serum MTL,GAS and VIP levels in occupational workers exposed to N,N-dimethylformamide

目的探讨职业性暴露二甲基甲酰胺(DMF)工人的血清胃动素(MTL)、胃泌素(GAS)及血管活性肽(VIP)水平的变化和意义。方法 124名DMF作业工人作为暴露组,35名健康者作为对照组。暴露组按肝功能是否异常和自诉有无腹痛、腹胀症状分为肝损伤组32人、腹痛组30人和无症状暴露组62人。无症状暴露组按暴露DMF空气浓度再分为高浓度组32人和低浓度组30人。利用酶联免疫吸附法检测各组血清MTL、GAS和VIP水平。结果 DMF暴露者血清MTL、GAS和VIP水平要高于对照组,其中无症状高浓度组分别为(57.72±21.36)、(34.92±11.87)和(2.43±1.10)ng/L明显高于对照组的(42.89±19.32)、(25.10±9.62)和(16.28±7.74)ng/L(P<0.05);肝损伤组、腹痛组与其他各组比较差异均有统计学意义(P<0.01)。结论职业性DMF暴露与作业人群血清胃动素、胃泌素和血管活性肽水平升高相关。

Objective To investigate serum motilin （MTL）, gastrin （GAS） and vasoactive intestinal peptide （VIP） levels among occupational workers exposed to N,N - dimethylformamide （DMF）. Methods 124 workers occupationally exposed to DMF were enrolled as the exposure group, and 35 healthy volunteers without any exposure to chemical toxicants or other hazards as the control group. According to the liver function and abdominal pain symptom, the exposure group was divided into liver injury group, abdominal pain group and non - symptom DMF exposure group. According to the concentration of DMF in working environment, the non - symptom DMF exposure group was further divided into non - symptom low concentration group and high concentration DMF exposure group. Serum MTL, GAS and VIP levels were determined by enzyme -linked immunosorbent assays in all groups. Results Serum MTL, GAS and VIP levels in the exposure group were higher than those in the control group. Comparing to control group, serum MTL, GAS and VIP levels in the non - symptom high concentration group （57.72 ±21.36, 34. 92 ± 11.87 and 2.43 ±1.10 （ng/L） ） were significantly higher （ P 〈 O. 05 ）. Also, there were significant differences in serum MTL, GAS and VIP levels between the liver injury group or the abdominal pain group and any other group （ P 〈 0. 01 ）. Conclusion Occupational exposure to DMF is associated with increased serum MTL, GAS and VIP levels.