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PDK1结构与功能研究进展 被引量：3

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摘要 PDK1是AGC蛋白激酶家族里面的一个丝氨酸/苏氨酸激酶。PDK1与PIP3的结合对于有效激活Akt等激酶,从而控制细胞生长、分化、生存、蛋白质翻译和葡萄糖代谢具有重要意义。本综述对PDK1的结构和功能进行了介绍,对于了解PDK1以及其调控的相关信号通路分子具有重要意义。
作者 李欣
机构地区 成都大学体育学院
出处 《攀枝花学院学报》 2014年第2期92-95,共4页 Journal of Panzhihua University
基金 四川省教育厅2013年度科研项目(项目编号:13ZB0340) 成都大学校基金项目(项目编号:2012ZJZ01)
关键词 PDK1 结构 功能
分类号 G804.2 [文化科学—运动人体科学]
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参考文献23

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同被引文献27

  • 1刘革修.3-磷酸肌醇依赖性蛋白激酶1结构和功能[J].生命科学,2005,17(5):387-391. 被引量：7
  • 2王平章,王欣,罗楹,吴俊.3-磷酸肌醇依赖性蛋白激酶-1激活AGC家族激酶的机制研究进展[J].中国生物化学与分子生物学报,2005,21(6):723-731. 被引量：9
  • 3Yu R K, Tsai Y T, Ariga T. Functional roles of gangliosides in neurodevelopment-anoverview of recent advances [ J ]. Neurochem Res,2012,37(6) :1230 -44.
  • 4Yuan Y, Guo Q, Ye z, et al. Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3 K-Akt pathway [ J ]. Brain Res,2011,1367 : 85 -93.
  • 5Chen L,Xiang Y,Kong L,et al. I-Iydroxysafflor yellow a protects a- gainst cerebral ischemia-reperfusion injury by anti-apoptotic effect- through PBK/Akt/GSK3~ pathway in rat [ J]. Neurochemical Res,2013,38 ( 11 ) :2268 - 75.
  • 6Bannister C M, Chapman S A. Ischemia and revascularization of the middle cerebral territory of the rat brain by manipulation of the blood vessels in the neck[ J]. Surg Neurol, 1984,21 (4) :351 - 7.
  • 7Tu X K, Yang W Z, Shi S S, et al. Baicalin inhibits TLR2/4 signa- ling pathway in rat brain following permanent cerebral ischemia [ J ]. Inflammation, 2011,34 ( 5 ) :463 - 70.
  • 8Liang M H, Chuang D M. Differertial roles of glycogen syntase ki- nase-3 isoforms in the regulation of transcriptional activation [ J ]. J Biol Chem,2006,281 (41) : 30479 - 84.
  • 9Choi Y K, Kim Y S, Choi I Y,et al. 25-hydroxy cholesterol in- duces mitochondfia-dependent apoptosis via activation of glycogen synthase kinase-3beta in PCI2 cells [ J ]. Free Radio Res,2008, 42(6) :544 -53.
  • 10Bo X, Mei Y, Wen J L, et al. Expression of oxidored nitro domain- containing protein 1 ( NOR1 ) impairs nasopharyngeal carcinoma cells adaptation to hypoxia and inhibits PDK1 expression [ J ]. Mol Cell Biochem,2014,393 (2) :293 - 300.

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攀枝花学院学报
2014年 第2期

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