重组人粒细胞集落刺激因子在小儿急性淋巴细胞白血病化疗中的应用

Use of recombinant human granulocyte colony stimulationg factor in children with acute lymphocytic leukemia during chemotherapy

目的 观察在小儿急性淋巴细胞性白血病 (ALL)强烈化疗后应用重组人粒细胞集落刺激因子 (rhG -CSF)的辅助治疗作用。方法 2 6例ALL患儿在进行强烈化疗时随机分为rhG -CSF治疗组和对照组 ,观察两组患者白细胞、中性粒细胞降低时间及感染发生率的变化。结果 与对照组相比强烈化疗后治疗组患儿白细胞、中性粒细胞降低时间明显缩短 (t =2 .51 ,P <0 0 1 ) ,感染发生率明显降低 ,发热时间明显缩短。结论 在强烈化疗后应用rhG -CSF可保证强烈化疗方案的顺利进行 ,提高化疗的疗效。

Objective To observe the adjuvant therapeutic effect of recombinant human granulocyte colony stimulating factor (rhG-GSF) after intensive chemotherapy in children with acute lymphocytic leukemia (ALL).Methods Twenty six children with ALL were classified into two groups:rhG-CSF group and control group.The reduced time periods of leukocytosis and grannulocyteosis and the infection rate in these two groups were observed.Results Compared with the control group,the time periods of leukocyfosis and granulocytosis were significantly shorter (t=2.51,P<0.01), the infection rate was significantly reduced,lamd febrile time significantly was shorter in the rhG-CSF group.Conclusions Use of rhG-CSF assures the coupletion of intensity chemotherapy protocol,thereby enhancing the effect of chemotherapy.