2型糖尿病伴非酒精性脂肪肝的临床分析

Clinical analysis of type 2 diabetes with nonalcoholic fatty liver

目的探讨2型糖尿病伴非酒精性脂肪肝(NAFLD)的临床特点。方法选取84例2型糖尿病伴NAFLD患者,另选取74例非NAFLD 2型糖尿病患者,比较分析两组患者的一般资料及生化指标。结果伴NAFLD组患者的胰岛素抵抗指数(HOMA-IR)、腰围(WC)、体重指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、天冬酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(GGT)均明显高于非NAFLD组(P<0.05);伴NAFLD组患者的高密度脂蛋白胆固醇(HDL-C)低于非NAFLD组(P<0.05)。结论2型糖尿病伴NAFLD与胰岛素抵抗有密切联系,临床应加强对体重、血糖、血脂、尿酸的有效控制,纠正代谢紊乱,改善胰岛素抵抗。

Objective To investigate the clinical features of type 2 diabetes with nonalcoholic fatty liver. Methods 84 patients with type 2 diabetes and NAFLD and 74 patients with type 2 diabetes were selected,general information and biochemical parameters of two groups were compared. Results In the NAFLD group,insulin resistance index （HOMA- IR）,waist circumference （WC）,body mass index （BMI）,triglyceride （TG）,total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）,uric acid （UA）,aspartate aminotransferase （AST）,alanine aminotransferase （ALT）,γ-glutamyl trans- ferase （GGT） were significantly higher than those in the non-NAFLD group （P〈0.05）.High-density lipoprotein choles- terol （HDL-C） in NAFLD group was less than that in the non-NAFLD group （P〈0.05）. Conclusion The realationship between type 2 diabetes with NAFLD and insulin resistance are closely,we should strengthen clinically effective control of body weight,blood glucose,cholesterol,uric acid,correct metabolic disorders and improve insulin resistance.