辅助生殖技术超促排卵中血清促黄体生成素对胚胎移植中妊娠结局的影响

Impact of assisted reproductive technology of super ovulation in serum luteinizing hormone effects on pregnancy outcome in embryo transplantation

目的探讨超促排卵中血清促黄体生成素（LH）对胚胎移植的影响。方法回顾性分析2013年1月～2014年1月在本中心进行体外受精／单精子注射（IVF／ICSI）118个新鲜周期的患者临床资料，将患者注射绒毛膜促性腺激素（HCG）日测定结果分为A组（LHI〉0．5U／L，75例）和B组（LH〈0．5U／L，43例）。对两组患者的重组人促卵泡激素（rhFSH）用药量、受精率、临床妊娠率、临床流产率进行比较。结果A组Gn用药量[（26．89±4．35）支1明显少于B组[（30．67±7．68）支]，两组差异有统计学意义（P〈0．05）。A组的受精率（84．0％）与B组（82．7％）比较，差异无统计学意义（P〉0．05）。A组的临床妊娠率（54．7％）与B组（53．5％）比较，差异无统计学意义（P〉0．05）。A组的临床流产率（6．7％）明显低于B组（11．6％），两组差异有统计学意义（P〈O．05）。结论在超促排卵中血清LH〈0．5U，L时，rhFSH用药量增加，临床流产率增加，对受精率和临床妊娠率无影响。

Objective To explore the effect of super ovulation in serum luteinizing hormone （LH） on the embryo trans- plantation. Methods Retrospectively analysis was performed on the clinical data of patients with 118 fresh cycle of IVF/ICSI in our center from January of 2013 to January of 2014.Patients were divided into group A （LH≥0.5 U/L,75 cases） and group B （LH〈0.5 U/L,43 cases） according to the determination results after the injection of human chorionic gonadotropin （HCG）.The rhFSH dosage,fertilization rate,clinical pregnancy rate,abortion rate of two groups were com- pared. Results The Gn dosage of patients in group A （26.89±4.35） doses was lower than that of group B （30.67±7.68） doses ,the difference was statistically significant between two groups （P〈0.05）.The fertilization rate of group A （84.0%） and group B （82.7%） had no statistical significance （P〉0.05）.The clinical pregnancy rate of two groups had no statistical significance （54.7% vs 53.5%,P〉0.05）.The clinical abortion rate of patients in group A （6.7%） was lower than that in group B （11.6%）,the difference was statistically significant （P〈0.05）. Conclusion The LH concentration of serum in the super ovulation less than 0.5 U/L can increase the rhFSH dosage and clinical abortion,and has no effect on the fertiliza- tion rate and clinical pregnancy rate.