国产左旋卡尼汀改善慢性充血性心力衰竭患者心功能的临床研究

Clinical study of L-carnitine improving heart function in patients with congestive heart failure

目的 :观察国产左旋卡尼汀 (L - carnitine,L - CN )治疗充血性心力衰竭 (CHF)患者的临床疗效。方法 :选择慢性 CHF患者 5 6例 ,随机分为两组 :对照组 (2 8例 )给予洋地黄、利尿剂、血管扩张剂、ACEI或β受体阻滞剂等常规药物 ;L - CN组 (2 8例 )在常规治疗的基础上加用国产 L - CN治疗。结果 :L - CN组心功能改善的临床显效率 (4 2 .9% )和总有效率 (89.3% )均较对照组 (2 5 .0 %和 6 0 .7% )显著提高 (P<0 .0 1) ,且无不良反应出现。 结论 :用 L- CN辅助治疗

Objective: To observe the effect of L carnitine ( L CN) in the treatment of congestive heart failure (CHF). Methods: Fifty six cases of chronic CHF randomly received routine treatment (Digitalis, diuretics, vasodilator, ACEI or βblocker) or L CN (3.0 g/d ,VD×10 d) with routine therapy. Results: The treatment efficiency of L CN group and control group were 89.3% and 60.7% ( P <0.01), respectively. No adverse reactions related to the drug were observed. Conclusion: L CN with routine therapy might be a safe way to the treat CHF. [