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胰岛素信号传导研究进展 被引量：1

Advancement in Mechanism of Insulin Signal Transduction
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摘要 胰岛素通过与胰岛素 受体结台发挥生理作用,胰岛素信号传导从胰岛素受体的激活开始,在细胞内信号分子蛋白的相互作用下,将信号传递下去。本文对胰岛素信号传导通路中重要的信号分子的研究进展作一综述。 insulin exerts its physiological ac- tion by binding with insulin receptor. The activation of insulin receptor is the start of insulin signal transduction. Insulin signal is then transferred through the mteraction of some intracellular signal molecules. This paper reviews the newest studies on some important intracellular molecules m insulin signal transduction passway.
作者 徐春 刘亚力
机构地区 武警总医院内分泌科
出处 《当代医学》 2001年第2期41-44,共4页 Contemporary Medicine
关键词 胰岛素受体 信号传导 磷酸化 insulin receptor, signal transduction, phosphorylation
分类号 R33 [医药卫生—人体生理学]
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参考文献10

  • 1Meie R,Hemmings BA.Regulation of protein kinase B[].Journal of Receptor and Signal Transductionn Research.1999
  • 2Dong LQ. Farris S,Christal J. et al.Site--directed mutagenesis and yeast twohybrid studies of the insulin and insulinlike growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin rece[].Journal of Molecular Endocrinology.1997
  • 3Dong LQ,Du H,Porter SG,Kolakowski LF,Lee AV,Mandarino LJ,Fan J,Yee D,Liu F,Mandarino J.Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10γ[].Journal of Biological Chemistry.1997
  • 4Cooper DR,Watson JE,Patel N, et al.Ectopic expression of protein kinase CbetaII,-delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells[].Archive of Biochemistry and Biophysics.1999
  • 5Sauvage M,Maziere P. Fathallah H,et al.Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes[].Fur J Biochem.2000
  • 6Sajan MP,Standaert ML. Bandyopadhyay G,et al.Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes[].Journal of Biological Chemistry.1999
  • 7Dong LQ. Landa LR,Wick MJ. et al.Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton[].Proceedings of the National Academy of Sciences of the United States of America.2000
  • 8Tsakiridis T,Tong P,Matthews B,et al.Role of the actin cytoskeleton in insulin action[].Microscopy Research and Technique.1999
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同被引文献4

  • 1张永伟,刘卓,左瑾,孟雁,方福德.细胞骨架与血糖调节[J].生命科学,2005,17(2):159-164. 被引量：11
  • 2Clark SF, Molero JC, James DE. 2000. Release of insulin receptor substrate proteins from an intracellular complex coincides with the de- velopment of insulin resistance. Journal Biology Chemisty, 275 : 3819 - 3826.
  • 3Porte DJ, Baskin DG, Schwartz MW. 2005. Insulin signaling in the central nervous system : a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes,54:1264 - 1276.
  • 4刘明明,叶德泳.糖原合成酶激酶-3β及其抑制剂研究进展[J].药学进展,2009,33(4):145-151. 被引量：7

引证文献1

当代医学
2001年 第2期

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