大肠癌患者血清VEGF水平的临床研究

Clinical Study on Serum Vascular Endothelial Growth Factor in Human Colorectal Carcinoma

目的：探讨血管内皮生长因子（ VEGF）在大肠癌患者血清中的水平及其临床意义。方法：应用 ELISA法，对 82例大肠癌患者血清的 VEGF水平进行测定，并同期检测 30名健康人的血清 VEGF水平作为对照。结果：大肠癌患者血清 VEGF水平明显高于正常人； VEGF水平与大肠癌肿瘤大小、血管侵犯、淋巴结受累及肝脏转移密切相关；随着临床病理分期（ Dukes分期）的上升， VEGF水平亦明显升高。 VEGF水平与肿瘤部位、组织学类型及患者的性别、年龄等因素无关。结论：血清 VEGF水平与大肠癌的浸润、转移密切相关，术前检测血清 VEGF水平，对预测大肠癌的侵袭和转移具有重要的临床意义。

Objective： This study was designed to determine the serum vascular endothelial growth factor (VEGF)level in human colorectal carcinoma and analyze its clinical significance. Methods： The level of serum VEGF was measured by ELISA kit (R＆ D,SYSTEM INC,USA) in 82 patients with colorectal carcinoma and 30 normal persons as the control group. Results： The level of serum VEGF in colorectal carcinoma was significantly higher than that of normal control. The level of serum VEGF was positively correlated with tumor size, vessel invasion, lymph-node metastasis. With upgrading of clinical-pathological stage(Dukes stage), the level of VEGF increased significantly, but its relation to tumor site, histological type, age, and sex was not significant. Conclusion： The level of serum VEGF is closely correlated to invasion and metastasis of colorectal carcinoma. Serum VEGF assay may be used to preoperatively predict invasion and metastasis of colorectal carcinoma.