摘要
利用SP免疫组织化学技术检测 5 5例肝细胞癌 (HCC)及其癌旁组织中p Stat3(Tyr70 5 ) ,c fos和c jun蛋白的表达。结果显示 :HCC中p Stat3,c fos和c jun蛋白阳性率和阳性强度均高于癌旁组织 (P <0 .0 1) ,且p Stat3与c fos和c jun蛋白表达强度均呈明显正相关 ,而在癌旁组织中p Stat3仅与c jun蛋白表达相关 ,提示Stat3蛋白的磷酸化可能是HCC发生的早期事件 ,并通过激活c jun和c fos基因使肝细胞恶性转化 ;癌旁肝组织中 ,p Stat3,c jun或c fos呈阳性表达的肝细胞可能是一种具有恶性潜能的癌前细胞群。
Expression of phosphorylated Stat3 (p Stat3), c fos and c jun proteins was detected by immunohistochemical technique in 55 hepatocellular carcinomas (HCC) and their surrounding liver tissues. The results showed that the positive rates and signal intensity of p Stat3, c fos and c jun protein in HCCs were significantly higher than those in pericarcinomatous tissues. The expressive intensity of c fos and c jun proteins was positively related to p Stat3 expression in HCCs, whereas the positive correlation of expressive intensity was only observed between c jun protein and p Stat3 in pericarcinomatous tissues. The data suggest that the phosphorylation of Stat3 may be an early event in hepatocarcinogenesis; the overexpression of p Stat3 protein, which activates c fos and c jun genes, may contribute to malignant transformation of hepatocytes; hepatocytes which expressed p Stat3, c fos or c jun proteins may be potentially malignant pre cancer cells in pericarcinomatous liver tissues. [
出处
《湖南医科大学学报》
CSCD
北大核心
2001年第1期17-19,共3页
Bulletin of Hunan Medical University
