甲氧凝胶用于牙周炎辅助治疗的疗效观察

Clinical Effects of Metronidazole-ofloxacin Gel as an Adjunct to Conventional Therapy for Periodontitis

目的 :评价甲氧凝胶作为牙周炎基础治疗辅助措施的临床效果。方法 :选择成人牙周炎患者 13例 ,每例患者口内至少有两个部位真性牙周袋≥ 4mm ,共统计 2 10个牙位点。基础治疗后 ,随机分为 3组。试验组用甲氧凝胶 ,标准组用甲硝唑棒 ,对照组用空白凝胶。采用牙周袋局部上药治疗 ,每周 1次 ,共治疗 12周。临床观察PD、PAL、GI、BOP、PLI等指标。结果 :甲氧凝胶组和甲硝唑棒组各临床指标改善均优于对照组 ,但甲氧凝胶组和甲硝唑棒组间疗效无显著差异。结论

Objective:This study was designed to evaluate the clinical effects of metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for periodontitis. Methods: 13 patients with adult periodontitis were selected and each of them had two or more sites with probing depth≥4mm, so totally 35 teeth were included in this study. After conventional therapy, the subjects were randomly divided into three groups: (1) experimental group application with MO gel, (2) standard group application with metronidazole stitus, and (3) control group application with placebo gel. Local application was performed once a week for 12 weeks. Clinical parameters including PD, PAL, GI, BOP, PLI was recorded after 6 weeks and 12 weeks respectively. Results: All clinical parameters from group of gel and group of metronidazole stilus were better than that from control group, while no significant difference was observed between MO gel group and metronidazole stilus group. Conclusion: It indicates local application with MO gel treatment as an adjunct to conventional therapy may lead to a more advantageous outcome for periodontitis.\;