替硝唑棒局部应用治疗牙周炎的细菌学研究

Study of Bacteriology on Local Application of Tinidazole Stilus in Treatment for Periodontitis

目的 :探讨局部应用替硝唑棒对牙周炎病原菌的抗菌作用。方法 :选择 41例牙周炎患者 ,局部应用替硝唑棒和甲硝唑棒前后采集龈下细菌并分离、培养 ,测定产黑色素厌氧杆菌、梭杆菌、优杆菌等牙周病原菌的检出变化。结果 :替硝唑棒对产黑色素厌氧杆菌、梭杆菌和普氏菌的清除率均高于甲硝唑棒。替硝唑棒和甲硝唑棒使用前后 ,龈下优势牙周病原菌的检出量均有显著性差异 ,但替硝唑棒的抗菌效果优于甲硝唑棒。结论 :局部应用替硝唑棒对牙周病原菌有明显的抗菌作用。

Objective:The study was designed to evaluate the antiseptic efficacy of Tinidazole stilus against periodontal pathogen. Methods:A total of 41 patients with periodontitis were included in this study. 26 of them were treated by Tindazole stilus and other 15 cases were treated by metronidazole stilus as controls. The prevalence of subgingival bacteria from both group were examined. Results: The eliminate rates for Black pigmented anaerobic rod (Porphyromonas gingivalis, Prevotella intermedius, Prevotella melaninogenicus), Fusobacteriums, Prevotella oris, Prevotella oralis, Eubacterium and Actinomyces were 95 8% 94 1%, 83 3% and 76 5%. The anti bacterial efficiency of Tinidazole against periodontal pathogen was significantly higher than that of metronidazole (P<0 05). Conclusion: It appears to be effective to use Tinidazole stilus as local application against periodontal pathogens.\;