早期胰岛素强化治疗联合生脉注射液对2型糖尿病血管炎症因子的影响

The effect of early intensive insulin therapy combined with Shengmai injection on vascular inflammation factor of type 2 diabetes

目的观察早期胰岛素强化治疗联合生脉注射液对气阴两虚证2型糖尿病治疗前后血管炎症因子白介素-6、肿瘤坏死因子(TNE-α)及气阴两虚证证候表现的变化。方法将48例2型糖尿病气阴两虚证随机分为治疗组和对照组,治疗组28例,对照组20例。对照组采用胰岛素强化治疗,治疗组在对照组的基础上加用生脉注射液。结果治疗后治疗组与对照组IL-6、TNF-α经统计分析差异有统计学意义(P<0.05),且治疗组较对照组能改善2型糖尿病气阴两虚证的证候表现。结论早期胰岛素强化治疗联合生脉注射液能降低2型糖尿病气阴两虚证患者炎症因子水平及改善气阴两虚证候表现。

Objective To observe early intensive insulin therapy combined Shengmai injection on vascular inflammatory cy- tokines interleukin-6 （IL-6）, tumor necrosis factor （TNF-α） and Qi and Yin deficiency syndromes changes of Qi and Yin deficiency syndrome of type 2 diabetes. Methods 48 patients with Qi and Yin deficiency syndrome of type 2 diabetes were randomly divided into treatment group and control group （28 cases in the treatment group, 20 cases in the control group）. The control group was given intensive insulin therapy. The treatment group was added Shengmai injection besides intensive insulin therapy. Results IL-6 and TNF-α in the treatment group and the control group after treatment had statistical differ- ence by statistical analysis （ P 〈 0.05）. The treatment group can improve the performance of type 2 diabetes syndrome of Qi and Yin deficiency more significantly than that of the control group. Conclusion Early intensive insulin therapy combined with Shengmai injection can reduce the levels of inflammatory factors in patients with type 2 diabetes Qi and Yin deficiency syndrome and improve syndrome performance.