新疆乌鲁木齐县中小学学生乙型病毒性肝炎疫苗免疫效果分析

Analysis of immunization effect on primary and middle school students With hepatitis B vaccine

目的了解中小学生乙肝疫苗免疫应答状况,为乙型病毒性肝炎(以下简称乙肝)预防控制提供科学依据。方法选择乌鲁木齐县3所中小学综合性学校的在校学生进行乙肝血清学检测,对乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(HBsAb)检测结果进行统计学分析。结果疫苗接种前中小学学生HBsAb阳性率为67.36%,免疫前小学生HBsAg阳性携带率(1.28%)低于初中学生(1.74%),男女生之间,汉族、回族、哈萨克不同民族之间差异无统计学意义。对中小学学生乙肝疫苗全程免疫1个月后HBsAb阳转率达到89.72%,乙肝疫苗接种后免疫无(弱)应答率为10.28%,无应答率中小学生间差异无统计学意义(P>0.05)。结论该县中小学学生HBsAb阳性率较低,对学生进行乙肝疫苗强化免疫非常必要。

[ Objective] To study the immune status of hepatitis B vaccine in primary and middle school students, and provide a sci- entific basis for hepatitis B prevention and control. [ Methods ] Hepatitis B serological test was adopted on 3 primary and middle school students in Urumqi County and the statistical analysis of HBsAg, anti-HBs was carried out. [ Results ] The HBsAb positive rate was 67.36% among primary and middle school students before vaccination. Pre-immune results showed that HBsAg positive rate of primary school students （ 1.28% ） was lower than that of middle school students （ 1.74% ） , without significant differences be- tween boys and girls, between Han, Hui, Kazakh ethnic. The test showed that seroconversion rate was 89.72% a month after full course of immunization. No/Weak response rate was 10. 28%, with significant difference between primary and middle school students （ P 〉 0.05 ）. [ Conclusion] HBsAb positive rate is relatively low among primary and middle school students in this county. Supplementary vaccination of hepatitis B is necessary for students.