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胃癌中P16的表达及其与预后的关系 被引量：2

Expression of P16 in gastric cancer and its correlation with prognosis
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摘要 目的 :研究多种肿瘤抑制基因 (MTS1)编码产物P16的表达及其与胃癌的临床病理指标及预后的关系。方法 :应用免疫组织化学LSAB方法 ,检测 6 5例胃癌、10例正常胃粘膜组织和 35例非癌病变组织中MTS1基因产物P16的表达。结果 :P16在胃癌中的表达阳性率明显低于正常胃粘膜和非癌性病变组织 (P <0 0 5 )。MTS1基因产物的表达与胃癌的分化程度呈正相关 ,与浸润、淋巴结转移呈负相关 ,经随访提示P16阳性者术后三年生存率高于阴性者。结论 :MTS1基因参与了胃癌的发展过程 ,并与胃癌的部分生物学行为有关。 Purpose:To study the expression of multiple tumor suppressor 1 (MTS1) gene products in gastric cancer and its correlation with clinicopathologcal indicators and prognostic significance. Methods:MTS1 gene products were observed in 65 gastric cancers, 10 normal gastric tissues and 35 non cancerous tissues with LSAB immunohistochemical methods.Results:The positive expression rates of P16 was lower in gastric cancer than that in the normal gastric tissues and non cancerous gastric disease tissues ( P <0 05). Expression of MTS1 gene products was positively related to the degree of differentiation, it was negatively related to invasive depth and lymph node metastasis, Patients with positive expression of P16 had higher 3 year survival rate than those with negative P16. Conclusions:MTS1 may play a role in the development of gastric cancer, and was partially related to biological behavior. Expression of P16 protein may serve as an important molecular biological indicator of diagnosis and prognosis of gastric cancer.
作者 范开席 仲伟霞 孙兰萍 李文梅 胡伟
机构地区 山东省肿瘤医院 江西医学院第一附属医院
出处 《中国癌症杂志》 CAS CSCD 2001年第1期14-16,共3页 China Oncology
基金 山东省医学科学院基金项目! (No :990 30 )
关键词 胃癌 MTS1基因 P16蛋白 免疫组织化学 预后 gastric cancer MTS1 gene P16 protein immunohistochemistry prognosis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献8

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同被引文献15

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引证文献2

中国癌症杂志
2001年 第1期

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