绝经后女性心脏X综合征患者性激素与β-内啡肽的相关性

Relationship between sex hormones and β-endorphin in postmenopausal women with cardiac syndrome X

目的研究性激素、β-内啡肽在绝经后女性心脏X综合征(CSX)患者中的关系。方法选取绝经后女性CSX的患者55例及健康无症状绝经后女性57名。所有入选者应用ELISA法测定性激素[包括雌二醇、孕酮、促黄体生成素(LH)、促卵泡刺激素(FSH)、睾酮]和β-内啡肽水平。结果与对照组相比,CSX患者血清雌二醇及血浆β-内啡肽水平均显著减低(P<0.05);血清FSH、LH浓度明显升高(P<0.05);雌二醇/睾酮比值明显降低(P<0.05);孕酮、睾酮有升高趋势,但两组比较差异无统计学意义。线性相关分析显示,CSX患者血清雌二醇与β-内啡肽呈正相关(P<0.05);LH与β-内啡肽呈负相关(P<0.05);雌二醇/睾酮比值、FSH与β-内啡肽均无明显相关性。多元线性回归显示,雌二醇、LH与β-内啡肽密切相关(P<0.05)。结论绝经后女性CSX患者雌激素缺乏引起LH升高,可能通过抑制β-内啡肽的释放,导致其疼痛敏感性增高。

Objective To investigate the relationship between serum sex hormones and β-endorphin in postmenopausal women with cardiac syndrome X （CSX）. Methods Fifty five postmenopausal women with cardiac syndrome X and 57 healthy women were enrolled in this study. ELISA was used to measure the serum levels of sex hormones [estradiol,progesterone,follicle-stimulating hormone （FSH）,luteinizing hormone （LH）and testosterone]and β-endorphin （β-EP）. Results The concentration of plasma estradiol and β-EP were significantly lower in CSX than that in control group （P＆lt;0.05 ）. The levels of LH and FSH were signifi-cantly higher in CSX than that in control group （P＆lt;0.05 ）. The levels of progesterone and testosterone be-came higher,but the difference between two kinds of sex hormones were not significantly. The linear correlation analysis showed that the serum estradiol was positively correlated with β-EP （P＆lt;0.05 ）. The serum LH was negatively correlated withβ-EP （P＆lt;0.05 ）. The serum FSH and estradiol/testosterone ratio were not found to be correlated with β-EP. Multivariate linear regression showed that estradiol and LH were closely related withβ-EP. Conclusion Lack of estrogen in postmenopausal women with CSX causes the secretion of LH,which probably by inhibiting the release ofβ-endorphin ,and then causes pain hypersensitivity in these patients.