期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CHL1在脑胶质细胞瘤中表达的临床意义

Clinical significance of CHL1 in glioma tumorigenesis express
下载PDF
导出
摘要 目的研究CHL1在脑胶质细胞瘤中表达的临床意义。方法采用RT-PCR和Western blot检测脑胶质细胞瘤原发组织和瘤旁组织中CHL1的表达,分析其与临床病理因素关系。结果 CHL1在脑胶质细胞瘤原发瘤组织中的表达低于相应的瘤旁组织。结论为研究脑胶质细胞瘤发生和进展提供了策略。 Objective To evaluate the diagnostic value of CHL1 in glioma patients.Methods RT-PCR and Western blot were used to examine the expression of CHL1 in samps, including 100 normal tissues and 30 primary tumors.Results CHL1 was low-regulated in glioma and related to LN.Conclusion Our results may provide a strategy for blocking glioma and progression.
作者 由庆军 杜依燃
机构地区 吉林省吉林市中心医院神经外科
出处 《中国现代药物应用》 2014年第8期3-5,共3页 Chinese Journal of Modern Drug Application
关键词 脑胶质细胞瘤 CHL1 临床意义 CHL1 Glioma tumorigenesis Clinical significance
分类号 R739.41 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1Alves TR, Lima FR, Kahn SA, et al. Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma. Life Sei, 2011(89):532-539.
  • 2Norden AD, Drappatz J, Wen PY. Antiangiogenic therapies for high-grade glioma. Nat Rev Neurol, 2009(11): 610-620.
  • 3Castro MG, Candolfi M, Kroeger K, et al.Gene therapy and targeted toxins for glioma. Curr Gene Ther, 2011(11):155-80.
  • 4VN Senehenko, GS Krasnov, AA Dmitriev, et al. Differential expression of CHL1 gene during development of major human cancers, PLoS One, 2011, 6(3): 15612-15617.
  • 5H Kamiguehi, V Lemmon. IgCAMs: bidirectional signals underlying neurite growth. Curr Opin .Cell Biol, 2000, 12(5):598-605.
  • 6Y. Li, DS Galileo.Soluble L1CAM promotes breast cancer cell adhesion and migration in vitro, but not invasion.Cancer Cell Int, 2010, 10(1):34.
  • 7N. Gavert, A. Vivanti, J. Hazin, et al. Ll-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers.Mol Cancer Res, 2011, 9(1):14-24.
  • 8A. Thies, M. Schachner, I. Moll, et al. Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma.Eur J Cancer, 2002, 38(13) : 1708-1716.
  • 9A. Rokman, AB Baffoe-Bonnie, E. Gillanders, et al. Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus.Hum Genet, 2005, 116(1-2):43-50.
  • 10E. N. Manderson, AH Birch, Z Shen, et al.Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer.Int J Gynecol Cancer, 2009, 19(4) :513-525.
中国现代药物应用
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部