HBsAg阳性孕妇及新生儿注射HBIG前后外周血T细胞亚群的变化

Change of peripheral blood T cell subsets about HBsAg positive pregnant women and infants after injection of HBIG

目的:探讨孕母HBsAg阳性患者及其新生儿注射乙型肝炎高效价免疫球蛋白(HBIG)前后对外周血中T细胞亚群的影响。方法:选取60例HBsAg阳性孕妇自愿在24、28、32周注射HBIG 200 U×3次,在注射HBIG前(自身对照组)及注射结束后检测外周血中T细胞亚群,另选取60例HBsAg阳性患者孕期没有注射HBIG的孕妇作为正常对照。在34周左右抽取静脉血检测外周血中T细胞亚群,比较正常对照组与注射组及注射前后外周血中T细胞亚群的变化。其新生儿出生即刻抽取外周血检测外周血中T细胞亚群及出生后立即注射HBIG 200 U,出生15 d注射HBIG 200 U,出生1个月时检测外周血中T细胞亚群,比较注射前后外周血中T细胞亚群的变化。结果:HBsAg阳性孕妇注射前后外周血中T细胞亚群比较,差异无统计学意义(P>0.05),注射组与正常对照组外周血中T细胞亚群的比较差异无统计学意义(P>0.05),其新生儿注射HBIG前后外周血中T细胞亚群差异无统计学意义(P>0.0.5)。结论:注射HBIG对孕母HBsAg阳性患者及其新生儿的外周血中T细胞亚群的水平无明显影响。

Objective： To explore the effect of T cell subsets in the peripheral blood about the female pregnant patients with HBsAg positive and newborns before and after the injection of HBIG. Methods： Sixty cases of hepatitis B surface antigen positive women voluntarily who using HBIG 200 U x 3 times, at week 24, 28, 32 were chosen. Before the injection of HBIG（ control group） and after the injection, we detected the peripheral blood T cell subsets. The other selected 60 patients with HBsAg positive pregnant women did not be injected HBIG as normal control group. At the end of 34 weeks, they were tested in the peripheral blood T cell subsets. Compared with the changes of peripheral blood T cell subsets between injection group and normal control group. And compared with the changes of peripheral blood T cell subsets before and after injection. The peripheral blood T cell subsets were instantly tested when they were born and injections of HBIG 200 U were immediately done, and when they were at 15 days old, injections of HBIG 200 U were done. At one month old, we detected the peripheral blood T cell subsets. We compared the changes of peripheral blood T cell subsets before and after injection. Results： There was no statistically significant difference between before injection group and after injection group（ P 〉 0.05 ）. They have no statistical significance between injection group and normal control group in the peripheral blood T cell subsets （ P 〉 0.05 ）. The newborns between before and after injection of HBIG, there were no statistically significant differences in neonatal peripheral blood T cell subsets. Conclusion： Injection of HBIG have no effects on newborns and mothers in the peripheral blood.