动脉介入治疗消化道肿瘤后腹膜淋巴结转移癌性疼痛的临床研究

目的评价动脉介入治疗消化道肿瘤后腹膜淋巴结转移癌性疼痛的临床价值。方法 77例患者随机分为对照组(n=31)和观察组(n=46)。前者采用药物止痛,而观察组采用奥沙利铂和5-氟尿嘧啶的方案经导管动脉介入化疗辅以药物止痛。观察2组疼痛缓解情况、止痛药用量、生活质量评分以及不良反应发生情况。结果 2组术后疼痛缓解率及吗啡使用量差异均有统计学意义(P<0.05);观察组患者的生活质量明显改善,同时未发生严重不良反应。结论动脉介入治疗消化道肿瘤后腹膜淋巴结转移癌性疼痛是安全有效的,是控制是后腹膜淋巴结转移癌性疼痛比较理想的方法。

Objective To evaluate the clinical value of artery interventional treatment for cancer pain of retroperitoneal lymph node metastasis from gastrointestinal tumors. Methods 77 patients were enrolled in our study from January 2008 to December 2012 in the PLA 113 Hospital. And they were randomly divided into control group （n=31 ） using the anodyne to control pain and study groups （n=46） using oxaliplatin and 5-fluorouracil transcatheter arterial infusion chemotherapy with the anodyne for pain. The evaluate efficacy such as pain relief, changes of anodyne dose, quality of life score and adverse events were observed in a month. Results After one week and one month the pain relief rates and the addition of morphine were both statistically significant differences between the two groups in the pain relief, changes of anodyne dose and quality of life score in a week. And the same changes in a month. Moreover, there were no serious adverse reactions in the study groups. Conclusion Artery interventional treatment for cancer pain of retroperitoneal lymph node metastasis from gastrointestinal tumors is safe and effective. And it is an ideal method to control the pain of the retroperitoneal lymph node metastases.