硫酸羟氯喹治疗风湿病的疗效分析

目的：评价硫酸羟氯喹治疗风湿病的疗效。方法选取2009年7月～2012年7月海丰县彭湃纪念医院收治的风湿病患者（主要为RA和痛风性关节炎患者）120例为研究对象，随机均分为2组（n=60）。对照组采用柳氮磺砒啶与甲氨蝶呤治疗，观察组同时采用硫酸羟氯喹治疗，对比治疗前后2组临床相关指标的变化情况、综合疗效以及不良反应发生情况。结果观察组关节肿胀数、关节压痛数、疼痛程度以及CRP几项指标均改善更显著；观察组总有效率91.7%，对照组仅为76.7%；2组不良情况出现率均为3.3%；综合疗效对比显示观察组明显更优（P＜0.05）。结论硫酸羟氯喹应用于风湿病的治疗的过程中，疗效确切，且具有较高的安全性，适合在临床推广。

Objective To assess the curative effect of hydroxychloroquine sulfate in the treatment of rheumatism. Methods 120 cases of patients with rheumatism（mainly for patients with RA and gouty arthritis）from July 2009 to July 2012, were randomly divided into two groups. the control group （n=60） use willow nitrogen cycling arsenic organism and methotrexate, the experimental group （n=60） were cured by hydroxychloroquine sulfate at the same time, Compared two groups changes of clinically relevant indicators before and after treatment, comprehensive curative effect and adverse conditions. Results The observation group joint swelling, joint tenderness, degree of pain and CRP indicators was more significantly;The observation group total efficiency were 91.7%, the control group total efficiency were 76.7%, the two groups adverse reactions rate were all 3.3%;The comprehensive curative effect comparison showed that the observation group was significantly better （P〈0.05）. Conclusion Hydroxychloroquine sulfate applys in treatment of rheumatism is definite efficacy, and has higher security, Is suitable for clinical promotion.