国产缓释沙丁胺醇治疗支气管哮喘的随机对照试验

Treatment by Slow released salbuterol for patients with asthma

目的 比较缓释沙丁胺醇 (沙博特 )和全特宁在支气管哮喘治疗中的作用。方法 采用随机对照试验方法 ,使用沙博特和全特宁分别治疗 2 0例哮喘患者 2周 ,观察在治疗前、后肺功能FEV1、FEV1%、PEF ,自我症状评分及喘乐宁用量的变化。结果 治疗后肺功能FEV1占预计值 %、PEF和自我症状评分均有显著改善 (P <0 .0 5 ) ,喘乐宁用量明显减少 (P <0 .0 5 ) ,沙博特和全特宁两组之间无显著差异。结论 沙博特治疗支气管哮喘具有与全特宁相似的疗效及安全性。

Objective In a RCT study, the safety and efficacy of sabot (a slow release salbuteral) and volmax (controlled release salbuterol) were compared in bronchial asthma. Methods 40 patients with moderate to severe asthma were randomly divided into two groups and treated by sabot or volmax for 2 weeks. The FEV 1%, peak expiratory flow (PEF), symptom score and use of rescue ventolin were measured to evaluate the effect of treatment. Results After treatment FEV 1%, PEF and symptom score improved and the need for inhaling short acting beta 2 agonis in both groups reduced significantly. There was no difference of these improvement between two groups. Conclusion The safety and efficacy of sabot for treatment of asthma was similar to volmax.