百草枯中毒肺损伤机制及治疗的研究现状

Research progress in mechanism of lung injury due to paraquat poisoning and its relevant treatments

百草枯中毒可引起多脏器损害,但肺是百草枯作用的主要靶器官。百草枯对肺脏的损伤主要是引起不可逆的肺纤维化。目前其损伤机制尚未完全阐明,可能与氧自由基损伤、免疫激活释放大量细胞因子等有关。治疗上目前无特效解毒剂,仍然以支持治疗为主,疗效较差。百草枯治疗的一些新方法如新型抗氧化剂、免疫抑制剂、血液透析和血浆灌流等取得了一定进展。本文对有关百草枯导致肺损伤的机制及其治疗新进展做一综述。

Poisoning by Paraquat（ PQ） leads to multiple organ failure. The main target organ for PQ toxicity is the lung. The specific mechanism of lung damage is pulmonary fibrosis. But the mechanism of PQ toxicity has not been fully understand yet. It may result from the PQ generates reactive oxygen species, activates immune system and releases inflammatory cytokines. No antidote or effective treatment to decrease PQ accumulation in the lung or to disrupt its toxicity has yet been developed. The managements of PQ poisoning rely mainly on supporting therapy. Some progress has been achieved in the treatment of PQ poisoning such as new anti-oxidant therapy, immunosuppressive agents, haemoperfusion and haemodialysis, but these methods have failed to alter the final outcomes in poisoned patients. This paper reviews the new progress in research of the mechanisms of lung toxicity caused by PQ-poisoning and its treatments.