齿科修复用Zr-Cu-AL-Ag合金的生物安全性评价

Biocompalibility evaluation of Zr-Cu-AL-Ag alloy for prosthodontic

目的:评价新型口腔修复用Zr-Cu-AL-Ag合金的生物安全性。方法:对Zr-Cu-AL-Ag合金进行细胞毒性试验、血液相容性试验以及急性全身毒性试验。结果:细胞毒性试验显示Zr-Cu-AL-Ag合金细胞毒性反应为0级,无细胞毒性;血液相容性试验Zr-Cu-AL-Ag合金溶血率数值小于5%,达到了生物材料对溶血率的要求。全身毒性试验显示无明显短期全身毒性。结论:Zr-Cu-AL-Ag合金拥有良好的细胞相容性、良好的血液相容性并且无急性全身毒性,可以初步满足其作为口腔植入材料的基本要求。

Objective： To evaluate the biocompatibility safety of high strength, high modulus of elasticity of Zr-Cu- AL-Ag alloy for prosthodontic. Method： The samples were tested with the cell toxicity test, the hemolysis test and the acute general toxicity test separately. Result： It was demonstration of cell toxicity experimentation that Zr-Cu-AL-Ag alloy the level of cell toxicity was 0 grade, no cell toxicity.The results of blood compatibility test was that Zr-Cu-AL-Ag alloy was less than 5 %, the requirement of the hemolysis rate of biological material was met.The study of acute general toxicity test showed that all samples had no acute general toxicity. Conclusion： The Zr-Cu-AL-Ag alloy indicate well cytocompatibility.well blood compatibility and no acute general toxicity, which can meet the basic requirement of being oral implant material.