慢性结肠炎与真菌变态反应相关性的观察

Correlation of chronic colitis and fungus allergy in 246 patients

目的 观察慢性结肠炎中过敏反应与真菌致敏原的相关性。方法 2 46例慢性结肠炎患者为实验组 ,61例慢性腹泻病人为对照组 ,用真菌变应原 3组共 6种对 2 46例病人进行皮肤敏感试验 ,并检测血清及肠分泌物嗜酸性细胞 ,血清SIgE。结果 实验组真菌变应原皮试阳性者 110例 (44 .72 % ) ,与对照组 (8.2 0 % )比较差异非常显著 (P <0 .0 1)。肠道分泌物嗜酸性细胞检查阳性率为 2 9.3 5 % ,真菌过敏原SIgE测定阳性率为 41.60 %。结论 部分慢性结肠炎病人与食入带有真菌变应原的食物导致的消化系变态反应有明显的相关性。

Objective To investigate the relationship between allergic reaction and fungus sensitinogen in patients with chronic colitis. Methods Skin test with 3 groups of fungus allergen (6 types), eosinophil detection in serum and intestinal secretion and serum specific IgE (SIgE) test were tested in 246 patients with chronic colitis. The other 61 patients with chronic diarrhea were served as control. Results Fungus positive was found in 110 patients (43.09%) in dermal fungus allergen test, but only 8.20% in control ( P <0.01). In patients with chronic colitis, the positive rates of eosinophil in intestinal secretion and specific IgE induced by fungus allergen were 29.35% and 41.60% respectively. Conclusion It is indicated that some patients with chronic colitis have correlation with allergic reaction of digestive system induced by food with fungus allergen.