血尿酸与男性脑出血有关

Relationship between serum uric acid and risk of cerebral hemorrhage in men

目的分析血尿酸水平对男性人群脑出血发病的影响。方法采用队列研究方法,以成年男性76 183人作为观察队列,按2006-2007年首次健康查体时的血尿酸四分位水平分组,平均随访4.04年,用Cox风险比例回归模型分析血尿酸对脑出血发病的影响。结果在血尿酸最高四分位组,研究对象的年龄较大,收缩压、体质量指数、总胆固醇、三酰甘油水平较高,空腹血糖水平较低,高血压、糖尿病和高血脂症病史及每天吸烟、饮酒比例较高。血尿酸四分位组(从低到高)的脑出血累积发病率分别为0.47%、0.46%、0.44%、0.72%。单因素Cox比例风险回归模型分析显示,血尿酸四分位组(从低到高)发生脑出血的HR(95%CI)分别为1.064(0.782～1.446)、1.010(0.740～1.378)、1.000(参照)、1.539(1.159～2.044);多因素Cox风险比例回归模型校正年龄、血压、血糖、血脂及主要病史、吸烟、饮酒等因素后显示,血尿酸四分位组脑出血的HR(95%CI)分别为1.043(0.756～1.439)、1.021(0.743～1.403)、1.000(参照)、1.393(1.041～1.863)。结论高血尿酸是男性脑出血的危险因素。

Objective To investigate the association between serum uric acid （SUA） concentration and cerebral hemorrhage risk in male population. Methods In this cohort study, a total of 76 183 men were included and cate- gorized into four groups according to their SUA quartiles levels determined in the health examination during 2006-- 2007. The candidates were followed up for an average of 4.04 years. The effect of SUA concentration on cerebral hemorrhage was estimated by Cox proportional hazard regression analysis. Results In the highest SUA quartile group, subjects had older age, higher body mass index, systolic blood pressure, levels of total cholesterol and trig- lycerid, higher rates in daily smoking, daily alcohol drinking, lower fasting plasma glucose. They also had more hypertension history, hyperlipidemia history, and antihypertensive or hypoglycemic medication history. The cumu- lative incidence of cerebral hemorrhage for four SUA quartiles were 0.47%, 0.46%, 0.44%, and 0.72%, respectively. The univariate Cox proportional hazard regression model showed that the HR （95% CI） of cerebral hemor- rhage across SUA quartiles were 1. 064（0.782-1.446）, 1.010（0.740-1.378）, 1.000（reference）, and 1. 539 （l. 159-2. 044）, respectively. After the adjustments for age, somking, dringking, blood pressure, blood glu- cose, blood lipid and other major dieases histories, the multivariate Cox proportional hazard regression model showed that the HR （95 % CI） of cerebral hemorrhage across SUA quartiles were 1. 043 （ 0. 756 - 1. 439 ） , 1. 021 （ 0. 743 - 1. 403）, 1. 000（reference）, and 1. 393（ 1. 041-1. 863）, respectively. Conclusion High SUA is a risk of developing cerebral hemorrhage in male population.