外周血ACE2及其抗体、Ang(1-7)与心力衰竭程度的关系

Correlation among plasma-soluble ACE2,anti-ACE2 and angiotensin(1-7)in patients with chronic heart failure

近年发现新的肾素-血管紧张素(RAS)轴,即血管紧张素转化酶2-血管紧张素(1-7)-Mas系统。血管紧张素转化酶(ACE)2可有效地将血管紧张素(Ang)Ⅱ降解为Ang(1-7),后者与其受体Mas结合可拮抗AngⅡ的心脏毒性,通过改善心肌缺血再灌注后心肌的收缩功能。

A total of 135 patients with CHF were enrolled in this study （63 males and 72 females, LVEF〈 50M）. The patients were divided into three groups： NYHA , NYHAm and NYHA IV group. The levels of plasma-soluble ACE2 in NYHAII, NYHAm and NYHA IV group were （45.59±7.83）U/L, （60. 81-4-16. 41）U/L and （73.30±22. 93）U/L; anti-ACE2 were （47.99±5.88）U/L, （54.31：t：18.82）U/L and（64.91±25.24）U/L; ang- （I-7） were （162.85-4-44.30）ng/L, （291.68±75.50）ng/L and （351.00±90.05）ng/L （all P〈0.05） statistical. Conelusion..Plasma-soluble ACE2, anti-ACE2 and angiotensin （1-7） maybe regarded as new brand and significant biological markers for diagnosis in patients with CHF.