早期帕金森病黑质致密部FA值量化研究

Quantitative research on FA value of substantia nigra pars compacta in early Parkinson′s disease

目的:使用1.5T磁共振仪观察早期帕金森病黑质致密部FA值的变化特点。方法:对20例早期帕金森病(PD)患者及28例性别、年龄与PD组相匹配的健康志愿者行MR T2WI和DTI扫描。在T2WI和DTI融合图像上手工勾勒黑质致密部内各兴趣区的范围,测量并记录黑质头、体、尾部及内外侧的FA值并进行统计学分析。结果:早期帕金森病患者黑质致密部的头、体及尾部的FA值均较正常对照组明显降低,以头部更明显(分别为0.201±0.030和0.254±0.050,P<0.05);两组在黑质内、外侧区的FA值差异亦均有统计学意义(P<0.05)。当黑质致密部头部FA值小于0.224,高度提示帕金森病可能。结论:黑质致密部的头部FA值降低对早期帕金森病的诊断有一定价值。

Objective：To observe the characteristic changes of FA value of substantia nigra pars compacta in early Parkinson＇s disease using 1.5T MR scanner. Methods：20 patients with early Parkinson＇s disease and 28 cases of gender and age-matched normal volunteers had MR scanning with T2 WI sequence and DTI. Taking T2 WI as reference, hand-sketched region of interest （ROD including head, body, tail as well as internal and external areas in substantia nigra were done, their FA values were measured. Statistical analysis was calculated. Results： FA values of substantia nigra pars compacta decreased significantly in early Parkinson＇s disease;The FA values of the head, body, tail of substantia nigra pars compacta were lower than those of the normal control group significantly, with the head as the most obvious, which was 0. 201 ± 0. 030 and 0. 254±0. 050 respectively,P〈0.05. When FA value of the head of substantia nigra pars eompacta was less than 0. 224, Parkinson＇s disease should be highly suspected. Conclusion： Lowering of FA values of the head of substantia nigra pars eom- pacta shows a certain value in the early diagnosis of Parkinson＇s disease.