老鹰茶的化学成分研究

Chemical constituents from Litsea Coreana L.

目的研究老鹰茶的化学成分。方法采用硅胶、ODS、Sephadex LH-20及制备型HPLC等色谱方法分离化合物，利用NMR、MS波谱学方法鉴定其结构。结果从老鹰茶70％乙醇回流提取物的乙酸乙酯部位和正丁醇部位分离得到9个化合物，分别鉴定为儿茶素（1）、表儿茶素（2）、菜豆酸（3）、山奈酚-3—O—β-D-芸香糖苷（4）、松属素-7-O—β-D-葡萄糖苷（5）、香树素-3—O-β—L-阿拉伯糖苷（6）、2，4，6-三羟基苯丁酮-2-O-β-D-葡萄糖苷（7）、腺苷（8）、（＋）-异落叶松脂醇-9—O—β-D-葡萄糖苷（9）。结论化合物3～9为首次从樟科木姜子属植物中分离得到，1、2为首次从该植物中分离得到。

Objective To study the chemical constituents in Litsea Coreana L. Methods The constituents were isolated and purified by silica gel, ODS, and Sephadex LH-20 column chromatographies as well as HPLC. Their chemical structures were elucidated on the basis of spectral data. Results The compounds were isolated from the ethyl acetate and n-butyl alcohol fractions of ethanol extract and identified as Catechin （1）, Epicatechin （2）, Phaseic acid （3） , Kaempferol-3-O-β-D-rutinose （4） , Pinocembrin-7 -O-β-D-glucopyranoside （5） , Aromadedrin- 3 -O-β-L-arabinopyranoside （6） , 2,4, 6-trihydroxybutyrophenone-2-O-β-D-glucopyranoside （7） , adenoside （8） , （ ＋ ） -isolariciresinal-9-O-β- D-glucopyranoside （9） , respectively. Conclusion Compounds 3 - 9 are firstly isolated from Litsea Lam. genus, and compounds 1 and 2 are isolated from this plant for the first time.