摘要
胰腺癌上调因子（PAUF）是新近发现的癌基因。其在胰腺癌高表达，能够通过激活CXCR4、B—catenin、TPL2／MEK／ERK、FAK／Scr等信号通路，增加胰腺癌细胞间的黏附性，促进胰腺癌血管生成及增加血管通透性等方式来促进胰腺癌迁徙、转移及进展。同时这些信号通路与吉西他滨耐药密切相关。因此我们推测PAUF亦参与调节吉西他滨对胰腺癌细胞的耐药。目前国内外尚缺乏PAUF调节胰腺癌细胞吉西他滨耐药及其机制方面的研究。因此，对其进行深入研究有利于明确胰腺癌化疗耐药机制及为胰腺癌治疗提供新的靶点。
Pancreatic adenocarcinoma up-regulated factor（PAUF）, a newly discovered gene, is highly expressed in pancreatic cancer. PAUF promotes the metastasis and progression of pancreatic cancer through many ways, such as the activation of signal pathway （CXCR4, β-catenin, TPL2/MEK/ERK,FAK/Scr）, increasing the adhesiveness of pancreatic cancer cells, promoting angiogenesis and vascular permeability. Simultaneously, CXCR4, β-catenin, TPL2/MEK/ERK and FAK/Scr are closely related with gemcitabine-resistance. Based on this theory, we infer that PAUF plays a role in gemcitabine-resistanee of pancreatic cancer cells. So far, no related research has been done domestic and overseas. The research may find a clue for the mechanism of chemotherapy-resistance and provide a new target spot for the therapy of pancreatic cancer.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2014年第4期317-320,共4页
Chinese Journal of Hepatobiliary Surgery
基金
基金项目：国家自然科学基金（81272756）
关键词
胰腺癌上调因子(PAUF)
胰腺癌
信号通路
吉西他滨
Pancreatic adenocarcinoma up-regulated factor （PAUF）
Pancreatic cancer
Signal pathway
Gemcitabine
