期刊文献+

额叶白质等微结构变化对帕金森并发认知障碍的影响 被引量:1

下载PDF
导出
摘要 目的探究额叶白质、前扣带束、肼胝体压部结构变化对帕金森并发认知障碍的作用及评定价值。方法将74例帕金森患者参照认知功能评定量表分为帕金森患者并发认知障碍组(PDD组,n=43)和未并发认知障碍组(PD-CogNL组,n=31),测量2组患者的额叶白质、前扣带束、肼胝体压部的FA值(部分各异性),基于统计学方法分析2组额叶白质、前扣带束、肼胝体压部结构的差异。结果 PDD组的额叶白质、前扣带束、肼胝体压部的FA值均低于PD-CogNL组,差异均有统计学意义(P<0.05)。结论额叶白质、前扣带束、肼胝体压部等微结构变化与帕金森并发认知障碍相关性显著,可用于临床帕金森患者并发认知功能障碍检测及评定的指标。
出处 《临床合理用药杂志》 2014年第13期109-110,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献4

  • 1邓兵梅.脑白质微结构改变与帕金森病认知功能损害的关系[D].广州:南方医科大学,2012.
  • 2Laura,Mark,Guerry,et al.A Comparison of Two Brief Screening Measures of Cognitive Impairment in Huntington' s Disease[J].Movement Disorders,2010,25 (13):2229-2233.
  • 3Hely MA,Reid WG,Adena MA,et al.The Sydney multicenter study of Parkinson's disease:the inevitability of dementia at 20 years[J].Mov Disord,2008,23 (6):837-844.
  • 4Sage CA,Van Hecke W,Peeters R,et al.Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis:Revisited[J].Hum Brain Mapp,2009,30(11):3657-3675.

同被引文献27

  • 1林艳,林峰.颈动脉粥样硬化斑块形成机制、危险因素与脑梗死的相关性探讨[J].神经病学与神经康复学杂志,2011,8(1):48-50. 被引量:10
  • 2Duan W, Gui L, Zhou Z, et al. Adenosine A (2A) receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice [ J ] . Neurol Sci, 2009,285 ( 1 ) :39-45.
  • 3Howlett JA, Northington FJ, Jennifer KL, et al. Cerebrovascular auto- regulation and neurologic injury in neonatal hypoxic-ischemic encepha- lopathy [ J ]. Pediatr Res ,2013,74 (5) :525-535.
  • 4Weintraub D, Dietz N, Duda JE, et al. Alzheimers disease pattern of brain atrophy predicts cognitive decline in Parkinsons disease [ J ]. Brain ,2012,135 ( Pt 1 ) : 170-180.
  • 5Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hor- mone actions[J]. Endocr Rev,2010,31 (2) :139-70.
  • 6Hom S, Heuer H. Thyroid hormone action during brain development: more questions than answers[ J]. Mol Cell Endocrinol,2010,315 ( 1- 2) :19-26.
  • 7Van Dyke K, Jabbour N, Hoeldtke R, et al. Oxidative-nitrosative stresses trigger type 1 diabetes:preventable in streptozotocin rats and edtectable in human disease [ J ]. Ann N Y Acad Sci, 2010,1203 : 138-45.
  • 8Andre C. CADASIL : pathogenesis, clinical and radiological findings and treatment [ J ]. Arq Neuropsiquiatr,2010,68:287-299.
  • 9Lai C H. Gray matter volume in major depressive disorder: a meta-a- nalysis of voxel-based morphometry studies [ J . Psychiatry Res, 2013,211 ( 1 ) :37-46.
  • 10滕厚军,赵瑛.慢性脑缺血神经胶质细胞损伤与血管性痴呆的研究进展[J].中国脑血管病杂志,2008,5(10):473-476. 被引量:16

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部