贲门松驰与胃食管反流病的相关性及其影响因素研究

Relationship between cardiac relaxion and gastroesophageal reflux disease

目的研究贲门松弛程度与胃食管反流病(GERD)之间的关系以及探讨影响贲门松弛程度的因素。方法内镜下收集贲门松弛病例171例和正常体检人员24例,GERD的诊断标准采用内镜下表现及胃食管反流症状积分量表双重诊断。内镜下对所有病例进行贲门松弛程度分级,并用SPSS 17.0统计软件分析贲门松弛程度与GERD的相关性,对比分析所有病例的性别、年龄、烟酒史、药物史、体质量指数等可能的危险影响因素与贲门松弛程度的相关性。结果随着贲门松弛程度的增加,患者的GERD发生率增加,差异具有统计学意义(P<0.05)。性别、年龄、饮酒、药物、睡眠及饱食等因素与贲门松弛程度相关(P<0.05),体质量指数及吸烟情况与贲门松弛程度无明显相关性(P>0.05)。结论贲门松弛在GERD的发病过程中起重要作用,流行病学调查结果可指导改善患者贲门松弛程度,进而一定程度上减轻患者的胃食管反流症状。

Objective To investigate the relationship between cardiac relaxion and gastroesophageal reflux disease （GERD） , and to explore the risk factors of cardiac relaxion. Methods GERD diagnosed by both endoscopy and RDQ questionare, 171 patients with cardiac relaxion and 24 normal subjects were collected. All of the cardiac relaxion cases were graded by endoscopy. The data were analyzed to assess the correlation of possible risk factors and cardiac relaxation degree by SPSS 17.0, including gender, age, smoking and alcohol history, medication history, body mass index. Re- suits With the cardiac relaxation degree increasing, the incidence of GERD was increased （P 〈 0.05）. The following factors were associated with cardiac relaxation degree, including gender, age, alcohol, drugs, sleep （P 〈 0.05）. How- ever, body mass index and smoking were not related to cardiac relaxation degree. Conclusion Cardiac relaxation plays an important role in the pathogenesis of GERD. These epidemiological findings can help the patients to decrease degree of cardiac relaxation and relieve the gastroesophageal reflux symptoms.