糖尿病和糖代谢异常/糖耐量异常与非酒精性脂肪肝的相关研究

Diabetes mellitus and impaired fasting glucose /impaired glucose tolerance related to nonalcoholic fatty liver disease

目的探讨非酒精性脂肪肝(NAFLD)与2型糖尿病、糖代谢异常/糖耐量异常和空腹血糖水平的关系。方法对2 412名健康体检者通过B超检查的方法,观察NAFLD的发病情况,并同时测量身高、体质量、血压,计算体质量指数(BMI),抽血测定空腹血糖、总胆固醇、甘油三酯以及高血压、冠心病的发病情况。比较这些因素在2型糖尿病、糖代谢异常/糖耐量异常和对照组之间的差异,以及NAFLD与空腹血糖的相关性。结果 (1)NAFLD、高血压病、BMI、收缩压、空腹血糖和甘油三酯在2型糖尿病、糖代谢异常/糖耐量异常和对照组之间差异有统计学意义(P<0.05)。(2)Logistic回归分析显示NAFLD与空腹血糖、BMI、舒张压和甘油三酯呈正相关(P<0.05),而与年龄呈负相关(P<0.01)。结论 NAFLD在糖代谢异常/糖耐量异常和2型糖尿病组中升高,NAFLD与空腹血糖、BMI、舒张压和甘油三酯呈正相关。血糖和NAFLD具有相互促进的作用,因此,治疗NAFLD的同时应关注患者血糖的控制。

Objective To explore the relationship of nonalcoholic fatty liver disease （NAFLD） with the differen groups of diabetes, impaired fasting glucose/impaired glucose tolerance and the fasting blood glucose. Methods The prevalence of NAFLD of 2 412 health checkups were observed in the Navy General Hospital of PLA, and the height weight, blood pressure were measured; body mass index （BMI） was eaculated; fasting blood glucose, total cholesterol triglycerides were examined, incidence of hypertension, coronary heart disease were counted. All of the data were com pared in diabetes, impaired fasting glucose/impaired glucose tolerance and normal glucose tolerance, and the relation ship between NAFLD and the fasting blood glucose was analyzed. Results There were significantly differences amon diabetes, impaired fasting glucose/impaired glucose tolerance and normal glucose tolerance in prevalence rate NAFLD, hypertension and levels of BMI, systolic blood pressure, fasting blood glucose and plasma triglyceride （P 0.05 ）. The incidence of NAFLD was positively correlated with fasting blood glucose, BMI, diastolic blood pressure ar plasma triglyeeride （P 〈0.05） by Logistic regression analysis, and negatively correlated with age（P 〈0.01 ）. Conclu sion The incidence of NAFLD was increased in diabetes, impaired fasting glucose/impaired glucose tolerance and re lated to fasting blood glucose, BMI, diastolic blood pressure and plasma triglyceride. The fasting glucose and NAFLD have mutual promotion effects, so for the treatment of NAFLD patients should pay attention to blood glucose control a the same time.