美他多辛治疗酒精性肝病临床研究

Clinical research of Metadoxine in treatment of alcoholic liver disease

目的探讨美他多辛治疗酒精性肝病临床价值,以期能为酒精性肝病的治疗提供参考。方法选取100例酒精性肝病患者为研究对象,嘱戒酒基础上给予美他多辛500 mg/次,口服,3次/d,连续服药治疗8周。观察患者治疗前后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、甘油三酯(TG)、总胆固醇(TC)、白球蛋白比率(A/G)变化及治疗期间药物不良反应发生情况。结果两组患者治疗前ALT、AST、GGT、TG、TC、A/G比较,差异无统计学意义(P>0.05);治疗后ALT、AST、GGT、TG、TC均较治疗前明显下降,A/G较治疗前升高;治疗前后组内比较,差异具有统计学意义(P<0.05),观察组较对照组改善更为明显(P<0.05);疗效评定:以生化指标进行疗效评定,观察组总有效率为82.00%,对照组总有效率为40.00%,对脂肪肝患者超声影像学检查结果进行评定,观察组总有效率为45.71%,对照组总有效率为19.44%,两组生化指标总有效率、超声影像学总有效率比较,差异具有统计学意义(P<0.05)。结论美他多辛治疗酒精性肝病能明显改善肝功能及降低血脂,无严重不良反应,可用于治疗酒精性肝病。

Objective To explore the clinical value of Metadoxine in treatment of alcoholic liver disease. Methods One hundred patients with alcoholic liver disease were selected as the research object, on the basis of temperance, Metadoxine was given 500 rag/time orally, 3 times/d, continuous medication treatment was 8 weeks. Alanine aminotrans- ferase （ALT）, aspartate aminotransferase （AST）, gamma glutamyl transpeptidase （GGT）, triglycerides （TG）, total cholesterol （TC） , white globulin ratio （A/G） before and after treatment, the occurrence of adverse drug reactions dur- ing the treatment were observed. Results There were no significant differences in ALT, AST, GGT, TG, TC, A/G between two groups before treatment （P 〉 0.05）. After treatment, ALT, AST, GGT, TG, TC were significantly de- creased compared with before treatment, the A/G was decreased, there were significant differences in interior-groups （P 〈 O. 05）. The improving was more significantly in the observation group compared with control group （P 〈 0.05 ）. Therapeutic effects were assessed with biochemical indexes, the total effective rates were 82.00% and 40.00% in observation group and control group; Examination of ultrasonic images in patients with fatty liver was evaluated, the total effective rates were 45.71% and 19.44% in observation group and control group. There were significant differences in the total effective rates of biochemical indexes and ultrasonic images between two groups （P 〈 0.05）. Conclusion Metadoxine can obviously improve liver function and reduce blood fat in treatment of alcoholic liver disease.