EphrinA1、ERα和ERβ在乳腺癌中的表达及其意义

Protein expressions of EphrinA1,ERα and ERβ in breast carcinomas and their significance

目的:研究乳腺癌中EphrinA1、ERα和ERβ蛋白的表达及其意义。方法:用免疫组织化学SP法检测130例乳腺癌组织中EphrinA1、ERα及ERβ蛋白的表达水平,研究其与各临床病理因素的关系。结果:130例乳腺癌组织中EphrinA1、ERα和ERβ的阳性率分别为59.23%、63.08%和53.08%。EphrinA1蛋白在乳腺癌的阳性表达率与临床分期、淋巴结转移和组织学分级显著相关(P<0.05);ERα蛋白阳性表达率与各临床病理因素均无显著相关(P>0.05);ERβ蛋白的阳性表达与组织学分级显著相关(P<0.05)。EphrinA1在乳腺癌中表达与ERα表达无显著相关(P>0.05);EphrinA1蛋白在乳腺癌中表达与ERβ蛋白显著相关(P<0.05)。结论:EphrinA1、ERα和ERβ可能在乳腺癌的发生发展中发挥重要作用。联合检测可评估乳腺癌的生物学行为,并指导临床用药和预测预后。

Objective：The protein expressions of EphrinA1, ERo~ and ER~ and their significance were studied in breast carcinomas. Methods：The protein expressions of EphrinA1, ERct and ER~ were detected by immunohistoehem- istry SP method in 130 breast carcinoma samples. Then their relationship to clinicopathologieal factors were studyed. Results：The total positive rates of EphrinA1, ERa and ERB were 59.23 %, 63.08 % and 53.08 % respectively among the 130 breast carcinoma cases. The positive expressions of EphrinA1 protein were associated with clinical stage, lymph node metastasis and histological grade（ P 〈 0.05 ）. The protein expressions of ERa was not associated with all the clinic -pathological factors（ P 〉 0.05 ）. The positive expression of ERi3 protein were associated with histological grade（ P 〈 0.05 ）. The positive rate of EphrinA1 was not related with ERa（ P 〉 0.05 ）. The exprssion of EphrinA1 protein was significantly correlated with the expression of ERI]（ P 〈 0.05 ）, the positive rate of EphrinA1 protein ex- pression increased when the positive rate of ER~ protein increased. Conclusion：EphrinA1 ,ERct and ERB may be in- volved in carcinogenesis and development procedures of breast carcinoma. The combined detection of EphrinA1, ERa and ERr3 can help to predict the clinical and pathologic characteristics of breast carcinoma. It is an important index to guide treatment, and predictive factors for breast cancer.