培美曲塞/吉西他滨分别联合顺铂对肺腺癌术后化疗的临床疗效观察

Clinical effect of pemetrexed gemcitabine respectively with cisplatin treatment of postoperative patients with lung adenocarcinoma

目的:观察培美曲塞(PMD)与吉西他滨(GEM)分别联合顺铂辅助治疗肺腺癌术后的疗效及毒副反应。方法:回顾性分析符合条件的115例肺腺癌术后患者,其中PP(PMD联合顺铂)组56例和GP(GEM联合顺铂)组59例,每例均完成4个周期辅助化疗,观察术后复发率及化疗毒副反应。结果:PP组疾病控制率94.6%,GP组疾病控制率91.5%,两组相比较术后复发率无统计学意义(P>0.05)。化疗毒副反应主要是骨髓抑制、胃肠反应、脱发、皮肤瘙痒等。PP组化疗毒副反应显著低于GP组,有统计学意义(P<0.05)。结论:PMD联合顺铂与GEM联合顺铂辅助治疗肺腺癌术后,两者治疗效果无明显差异,但PMD联合顺铂化疗毒副反应明显较轻,可作为肺腺癌术后辅助化疗的优先推荐用药。

Objective ：To observe the curative effects and sid- effects of the adjuvant treatment to postoperative patients with lung adenocarcinoma after given pemetrexed（PMD） and gemcitabine （GEM） respectively with cisplatin. Methods：Retrospectively analyze 115 eligible postoperative patients with lung adenocarcinoma ,56 of PP group and 59 of GP group, accomplished 4 -periodic adjuvant chemotherapy and observe their recurrence rate and side - effects. Results： There was no statistical significance （ P 〉 0.05 ） of the recurrence rate between PP group with the disease control rate of 94.6% and GP group 91.5%. The main side - effects of chemotherapy were myelosuppression,gastro- intestinal reaction, aopecia, cutaneous pruritus. The side - effects of PP group were dramaticlly fewer than those of GP group（P 〈 0.05）. Conclusion： There was no obvious difference of cure postoperative patients with either PEM with cisplatin or GEM with cisplatin, however, GEM with cisplatinhas has fewer side - effects significantly. PEM can be preferentially recommended as an adjuvant chemotherapy of postoperative patients with lung adenocarcinoma.