摘要
目的:采用免疫组化技术,分析DEK基因在结直肠癌患者中的表达情况及其与预后的相关性。方法:运用免疫组化SP法,检测DEK基因在169例结直肠癌患者肿瘤组织及癌旁组织中的表达情况,并运用统计分析软件分析DEK表达水平与结直肠癌患者预后的相关性。结果:DEK的表达率在结直肠癌组织(85/169,50.30%)明显高于癌旁正常组织(28/169,16.57%),差异具有统计学意义(P<0.01)。DEK在肿瘤组织中的表达情况与病人年龄、性别、肿瘤分化程度、TNM分期及肿瘤大小等因素无相关性,与总生存率(OS)显著相关(P<0.05)。结论:DEK表达水平与结直肠癌预后密切相关,DEK高表达的结直肠癌患者预后较差。
Objective :To analyze DEK gene expression and prognostic significance in human colorectal carcinoma by using immunohistochemical techniques. Methods :Immunohistochemical SP method was used to test the expression of DEK gene in 169 eases of colorectal cancer tissue and para - carcinoma tissue, and statistical analysis software was used to analyze the correlation between DEK gene expression and prognostic significance in human colorectal carcino- ma. Results:The expression rate of DEK in colorectal cancer tissue 85/169 (50.30%) was significantly higher than those in para - carcinoma tissue,28/169 ( 16.57% ) ( P 〈 0.01 ). The level of DEK expression in the tumor tissues was irrelevant to age, gender, differentiated degree, TNM stage and location, but significantly correlated with overall survival(OS) ( P 〈 0.05 ). Conclusion: DEK expression is closely related to the prognosis of colorectal cancer. There will be poor prognosis for colorectal cancer patients with high DEK expression.
出处
《现代肿瘤医学》
CAS
2014年第4期875-878,共4页
Journal of Modern Oncology
关键词
DEK
结直肠癌
免疫组化
生存分析
DEK
colorectal cancer
immunohistochemical
survival analysis