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miR-519在肿瘤中的研究进展 被引量：1

Research progress on cancer related miR-519
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摘要 肿瘤的发生发展为复杂的多基因事件,microRNAs(miRNAs)参与其中并发挥重要作用。miRNAs是由长度为18-25个核苷酸组成的的非编码单链小RNA分子,通过与特定的靶mRNA结合来抑制靶基因转录或蛋白翻译从而沉默靶基因的表达,作为抑癌或致癌因子与靶基因共同作用参与肿瘤发生、发展。本文从miR-519的生成与组织分布、靶基因及相关肿瘤作用机制等方面进行综述。 The tumorigenesis of cancer is a complex process which involved oncogenes and anti - oncogenes. Re- cently studies had proved that miRNAs played an important role in this course, miRNAs are 18 -25nt no - coding sin- gle -stranded RNA molecules. They regulate the expression of genes by inhibiting the translating process of target mRNA through combining the specific target mRNA. miRNAs are closely related to the oncurrence and development of cancer. We review the research progress （ maturing process tissue expression, target gent and related tumor mecha- nism） of miR- 519 in different cancers.
作者 朱迎 陈妍珂 董健 王晓霏 吕毅 程继文
机构地区 西安交通大学医学院第一附属医院肝胆外科 西安交通大学医学院遗传学与分子生物学系环境与疾病相关基因教育部重点实验室
出处 《现代肿瘤医学》 CAS 2014年第4期944-946,共3页 Journal of Modern Oncology
基金 国家自然科学基金资助项目(编号:81101873)
关键词 肿瘤 微小核糖核酸-519 靶基因 cancer miR - 519 target gene
分类号 R730 [医药卫生—肿瘤]
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参考文献21

  • 1Sun Y,Koo S,White N,et al.Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs[J].Nucleic Acids Res,2004,32 (22):e188.
  • 2Garzon R,Calin GA,Croce CM.MicroRNAs in Cancer[J].Ann Review Med,2009,60:167-179.
  • 3Lu J,Getz G,Miska EA,et al.MicroRNA expression profiles classify human cancers[J].Nature,2005,435 (7043):834-838.
  • 4Gaur A,Jewell DA,Liang Y,et al.Characterization of microRNA expression levels and their biological correlates in human cancer cell lines[J].Cancer Res,2007,67(6):2456-2468.
  • 5Lee Y,Ahn C,Han J,et al.The nuclear RNAse Ⅲ Drosha initiates microRNA processing[J].Nature,2003,425 (6956):415-419.
  • 6Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
  • 7Bentwich I,Avniel A,Karov Y,et al.Identification of hundreds of conserved and nonconserved human microRNAs[J].Nature Genet,2005,37 (7):766-770.
  • 8Abdelmohsen K,Kim MM,Srikantan S,et al.miR-519 suppresses tumor growth by reducing HuR levels[J].Cell Cycle(Georgetown,Tex),2010,9(7):1354-1359.
  • 9Fornari F,Milazzo M,Chieco P,et al.In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21,PTEN,AKT3 and TIMP2[J].J Pathol,2012,227 (3):275-285.
  • 10Hou YY,Cao WW,Li L,et al.MicroRNA-519d targets MKi67 and suppresses cell growth in the hepatocellular carcinoma cell line QGY-7703[J].Cancer Lett,2011,307 (2):182-190.

二级参考文献26

  • 1Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast and prostate canced[J].Science,1997,275(5308):1943-1947.
  • 2Tolkacheva T,Boddapati M,Sanfiz A,et al.Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383[J].Cancer Res,2001,61(13):4985-4989.
  • 3Hu Y,Li Z,Guo L,et al.MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells[J].Arch Biochem Biophys,2007,467(1):1-9.
  • 4Yamada KM,Araki M.Tumor suppressor PTEN:modulator of cell signaling,growth,migration and apoptosis[J].Cell Sci,2001,114(13):2375-2382.
  • 5Halu JH,Eng C.Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis[J].Cancer Res,2005,65(18):8096-8100.
  • 6Hamada K,Sasaki T,Koni PA,et al.The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis[J].Genes Dev,2005,19(17):2054-2065.
  • 7Kaper F,Dornhoefer N,Giaccia A.Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions[J].Cancer Res,2006,66(3):1561-1569.
  • 8Vasudevan KM,Gurumurthy S,Rangnekar VM.Suppression of PTEN expression by NF-kappa B prevents apoptosis[J].Mol Cell Biol,2004,24(3):1007-1021.
  • 9Freeman DJ,Li AG,Wei G,et al.PTEN tumor supressor regulates p53 protein levels and activity through phosphatase-dependent and independent mechanisms[J].Cancer Cell,2003,3(2):117-130.
  • 10Mayo LD,Seo YR,Jackson MW,et al.Phosphorylation of human p53 at seine 46 determines promoter selection and whether apoptosis is attenuated or amplified[J].Biol Chem,2005,280(28):25953-25959.

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现代肿瘤医学
2014年 第4期

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