乳腺癌血清sMICA含量检测的临床意义

Clinical Significance of Serum sMICA in the Diagnosis of Breast Cancer

目的检测乳腺癌血清中sMICA水平,研究其单独及联合CA153检测对于乳腺癌诊断的意义。方法 ELISA法检测56例乳腺癌血清、69例乳腺良性病血清及75例健康体检者血清中sMICA水平,分析其与临床病理参数的关系。雅培免疫发光法检测其CA153浓度,并分析其与sMICA对于乳腺癌诊断的优缺点。结果乳腺癌患者血清中sMICA及CA153浓度均显著高于乳腺良性病患者及健康体检者;其中sMICA水平与乳腺癌临床分期呈正相关,淋巴结转移者sMICA浓度显著高于未转移者,与年龄及分级无明显相关性;sMICA、CA153及两者联合检测诊断乳腺癌的敏感度分别为67.86%、71.43%和92.86%。结论 sMICA可为乳腺癌病情评价提供新的参考指标,联合CA153能提高诊断性能,降低临床漏检率。

Objective To evaluate the value of sMICA and CA153 in the diagnosis of breast cancer.Methods The serum concentration of sMICA and CA153 in the breast cancer patients（56 cases）,benign breast disease patients（69 cases） and healthy women（75 cases） were detected by ELISA kit and i2000 Immunochemistry Analyzer respectively.Results The serum concentration of sMICA and CA153 in the breast cancer patients were obviously higher than those of benign breast disease patients and healthy women.The sMICA in breast cancer with TNM stage （Ⅲ ＋ Ⅳ） were dramaticlly higher than that of TNM stage（Ⅰ ＋ Ⅱ） （P ＜ 0.05）,and also higher in the breast cancer patients with axillary lymph node metastasis.The diagnostic sensitivity of combined measurement was 92.86％.Conclusion The combined measurement of serum sMICA and CA153 significantly increased the sensitivity for diagnosis of breast cancer and provided useful information for early diagnosis of disease in patients with breast cancer.