丁苯酞软胶囊对急性脑梗死患者氧化损伤及抗氧化能力的影响

Effects of dl-3-n-butylphthalide soft capsules on oxidative damage and antioxidant capacity in patients with acute cerebral infarction

目的研究丁苯酞对急性脑梗死患者氧化损伤及抗氧化能力的影响。方法选择急性脑梗死患者62例,分为实验组(添加丁苯酞软胶囊)和对照组(未添加丁苯酞软胶囊),所有患者均采用Fenton法测定血清活性氧(ROS)水平和ELISA法检测患者的血清总抗氧化能力(T-AOC)水平,并比较两组的差异。结果治疗后1周实验组患者的血清ROS水平低于对照组,差异有统计学意义(P<0.05);治疗后1周实验组患者的血清T-AOC水平较对照组明显升高,差异有统计学意义(P<0.05);实验组患者的血清T-AOC水平治疗后较治疗前升高明显,差异有统计学意义(P<0.05);实验组2周后NHISS评分低于对照组,差异有统计学意义(P<0.05)。结论丁苯酞可能通过减少ROS,提高机体总抗氧化能力,达到对神经元的保护,从而有效改善神经功能缺损症状。

Objective To investigate the effects of dl-3-n-butylphthalide （NBP） on the oxidative damage and antioxidant capacity in patients with acute cerebral infarction. Methods Sixty-two patients with acute cerebral infarction were divided into NBP group （given NBP soft capsules） and control group （not given NBP soft capsules）. Serum reactive oxygen species （ROS） and total antioxidant ca- pacity （T-AOC） were measured by Fenton reaction and enzyme-linked immunosorbent assay and compared between the two groups. Re- suits One week after treatment, the NBP group had a significantly lower serum ROS level （P 〈 0.05） and a significantly higher ser- um T-AOC （P 〈 0.05 ）, as compared with the control group. The NBP group showed a significant increase in serum T-AOC after treat- ment （P 〈 0.05 ）. Two weeks after treatment, the NBP group had a significantly lower NHISS score than the control group （ P 〈 0.05）. Conclusions NBP can protect nerve cells from oxidative damage through reducing ROS and increasing T-AOC, thus allevia- ting neurological deficit symptoms.