神经阻滞治疗老年带状疱疹后神经痛但不影响患者外周血CD4^+CD25^+Foxp3^+调节性T细胞的数量

NERVE BLOCKAGE FOR THE TREATMEAT OF POST HERPETIC NEURALGIA OF ELDLY DATIENTS WITHOUT AFFECTING THE NUMBER OF CD4^+CD25^+Foxp3^+ REGULATORY T CELLS IN PERIPHERAL BLOOD

目的:探讨神经阻滞治疗对老年带状疱疹后神经痛(post herpetic neuralgia,PHN)的临床疗效及对患者外周血CD4+CD25+Foxp3+调节性T细胞(CD4+CD25+Foxp3+Treg)的影响。方法:采用流式细胞术检测43例老年PHN患者经神经阻滞治疗前后及40例健康对照者外周血CD4+CD25+Foxp3+Treg的表达及运用视觉模拟评分(visual analogue scale,VAS)和睡眠质量评分(quality of sleep,QS)评价治疗效果。结果:患者VAS评分和QS评分较治疗前均显著下降(P<0.01);外周血CD4+CD25+、CD4+CD25+Foxp3+Treg的表达量治疗前后均高于健康对照组(P<0.05),但患者自身治疗前后无明显差异(P>0.05)。结论:老年带状疱疹后神经痛患者存在机体免疫调节功能紊乱;神经阻滞治疗能迅速缓解老年带状疱疹后神经痛,对带状疱疹后神经痛也有较好的预防作用,但对机体免疫调节功能无明显作用。

Objective：To observe the effect of nerve blocks for treating eldly patients with post herpetic neuralgia （PHN） and its effect on CD4^＋CD25^＋Foxp3^＋ regulatory T cells （CD4^＋CD25^＋Foxp3^＋ Treg） in peripheral blood.Methods：The expression of CD4^＋CD25^＋Foxp3^＋ Treg was detected by flow cytometry （FCM） in 43 cases of elder patients with PHN before and after treatment and 40 cases of healthy control group.Visual analog scale （VAS） and sleep quality score （QS） were evaluated before and after treatment.Results：The scores of VAS and QS decreased significantly after treatment （P 〈 0.01） ; and the CD4^＋CD25^＋、CD4^＋CD25^＋Foxp3^＋ Treg were significantly higher in the peripheral blood from eldly PHN patients before and after treatment than that of healthy control group （P 〈 0.05）,but there was no statistically significant difference between patients before and after treatment （P 〉 0.05）.Conclusion：Nnerve block is an effective treatment and for prevention of PHN in eldly patients,without affecting the expression of CD4^＋ CD25^＋ Foxp3^＋ regulatory T cells in peripheral blood.